Other substances

Oleanolic acid

A pentacyclic triterpenoid.

Phase of research

Potential treatment - pre-clinical evidence

How it helps

Antiviral

Drug status

Natural product

2
 Supporting references
0
 Contradictory references
10
 AI-suggested references
0
 Clinical trials

General information

Oleanolic acid is a pentacyclic triterpenoid plant metabolite (ChEBI).

Oleanolic acid on PubChem
Oleanolic acid on Wikipedia

Synonyms

Oleanic acid

 

Structure image - Oleanolic acid

C[C@]12CC[C@@H](C([C@@H]1CC[C@@]3([C@@H]2CC=C4[C@]3(CC[C@@]5([C@H]4CC(CC5)(C)C)C(=O)O)C)C)(C)C)O

Supporting references

Link Tested on Impact factor Notes Publication date
Hijacking SARS-Cov-2/ACE2 receptor interaction by natural and semi-synthetic steroidal agents acting on functional pockets on receptor binding region
ACE2 Preprint 		in vitro Jun/11/2020
The potential of Paritaprevir and Emetine as inhibitors of SARS-CoV-2 RdRp
RdRpol Small molecule In silico 		in silico 2.80

Predicted to inhibit the SARS-CoV-2 RNA-dependent RNA polymerase.

 Dec/02/2020

AI-suggested references

Link Publication date
Molecular docking and dynamics study to explore phytochemical ligand molecules against the main protease of SARS-CoV-2 from extensive phytochemical datasets.
Aug/05/2021
Molecular docking and simulation studies of natural compounds of Vitex negundo L. against papain-like protease (PLpro) of SARS CoV-2 (coronavirus) to conquer the pandemic situation in the world.
Nov/30/2020
Screening of potential spike glycoprotein / ACE2 dual antagonists against COVID-19 in silico molecular docking
Dec/10/2021
A Review of Medicinal Plants with Antiviral Activity Available in Bangladesh and Mechanistic Insight Into Their Bioactive Metabolites on SARS-CoV-2, HIV and HBV.
Nov/08/2021
Arjunetin as a promising drug candidate against SARS-CoV-2: molecular dynamics simulation studies
Sep/17/2021
Modeling the Structure-Activity Relationship of Arbidol Derivatives and Other SARS-CoV-2 Fusion Inhibitors Targeting the S2 Segment of the Spike Protein
Mar/03/2022
Anti-COVID drugs: repurposing existing drugs or search for new complex entities, strategies and perspectives
Jul/23/2020
Eugenol, a Component of Holy Basil (Tulsi) and Common Spice Clove, Inhibits the Interaction Between SARS-CoV-2 Spike S1 and ACE2 to Induce Therapeutic Responses
Oct/22/2021
Predictive medicinal metabolites from Momordica dioica against comorbidity related proteins of SARS-CoV-2 infections
May/08/2022
Identification of phytochemical inhibitors against main protease of COVID-19 using molecular modeling approaches
Jul/03/2020
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