Oleandrin
A cardiac glycoside.
General information
Oleandrin is a bioactive (e.g. antiviral and antineoplastic) lipid-soluble cardiac glycoside abundant in Nerium oleander extract (Plante et al., 2021).
Oleandrin on DrugBank
Oleandrin on PubChem
Oleandrin on Wikipedia
Synonyms
Foliandrin; Neriolin; Neriostene; Folinerin
C[C@H]1[C@@H]([C@H](C[C@@H](O1)O[C@H]2CC[C@]3([C@@H](C2)CC[C@@H]4[C@@H]3CC[C@]5([C@@]4(C[C@@H]([C@@H]5C6=CC(=O)OC6)OC(=O)C)O)C)C)OC)O
Supporting references
| Link | Tested on | Impact factor | Notes | Publication date |
|---|---|---|---|---|
|
Antiviral activity of oleandrin and a defined extract of Nerium oleander against SARS-CoV-2
Small molecule Animal model In vitro Mixed substance |
Vero CCL81 cells; Vero E6 cells; golden Syrian hamsters; SARS-CoV-2 strain USA-WA1/2020 | 4.55 | Inhibited SARS-CoV-2 infection in Vero cells with an EC50 as low as 7.07 ng/ml when administered prophylactically and assessed 48 hours post infection. Therapeutic treatment efficacy was observed, as well. |
Mar/03/2021 |
AI-suggested references
| Link | Publication date |
|---|---|
|
Antiviral Effects of Oleandrin.
|
Nov/16/2020 |
