Other substances

Ochromycinone

A STAT3 inhibitor.

Phase of research

Potential treatment - pre-clinical evidence

How it helps

Antiviral

Drug status

Experimental

1
 Supporting references
0
 Contradictory references
0
 AI-suggested references
0
 Clinical trials

General information

Ochromycinone is a STAT3 dimerization inhibitor with anti-SARS-CoV-2 activity in Calu-3 cells but not in Vero E6 cells (Park et al. 2021).

Ochromycinone on DrugBank
Ochromycinone on PubChem

Synonyms

STA-21; 8-Hydroxy-3-methyl-3,4-dihydrotetraphene-1,7,12(2H)-trione

 

Structure image - Ochromycinone

CC1CC2=C(C(=O)C1)C3=C(C=C2)C(=O)C4=C(C3=O)C=CC=C4O

Supporting references

Link Tested on Impact factor Notes Publication date
Differential Signaling and Virus Production in Calu-3 Cells and Vero Cells upon SARS-CoV-2 Infection
Small molecule In vitro 		Vero E6 cells; Calu-3 cells 3.47

Manifests anti-SARS-CoV-2 activity in Calu-3 cells but not in Vero E6 cells. The reason might be differential signalling and virus production in these cell lines.

 Jan/28/2021
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