NYBSP-2
A chemically modified peptide targeting SARS-CoV-2 Spike protein.
General information
NYBSP-2 is a hydrocarbon-stapled peptide derived from an hACE2 α-helical region (Curreli et al., 2020).
Supporting references
| Link | Tested on | Impact factor | Notes | Publication date |
|---|---|---|---|---|
|
Stapled Peptides Based on Human Angiotensin-Converting Enzyme 2 (ACE2) Potently Inhibit SARS-CoV-2 Infection In Vitro
Biophysical assay Peptide In vitro |
in vitro biophysical assay; HT1080/ACE2 cells; A549/ACE2 cells; Vero E6 cells; Sars-CoV-2 pseudovirus single-cycle assay; authentic SARS-CoV-2 strain US_WA-1/2020 | 6.78 | Inhibited SARS-CoV-2 pseudovirus in a single-cycle assay with IC50 of ca. 2.9 μM and 2.68 μM in HT1080/ACE2 and A549/ACE2 cells, respectively. Completely blocked SARS-CoV-2-induced cytopathic effect in Vero E6 cells at ca. 33 μM. |
Dec/11/2020 |
