Other substances

NSC Ex/Mv

Murine neural stem/progenitor cell exosomes/microvesicles.

Phase of research

Potential treatment - pre-clinical evidence

How it helps

Antiviral

Drug status

Experimental

1
 Supporting references
0
 Contradictory references
0
 AI-suggested references
0
 Clinical trials

General information

NSC Ex/Mv are murine neural stem/progenitor cell extracellular vesicle products. The have been shown to support innate and adaptive immune responses against SARS-CoV-2 pseudovirus. Their activity might be (partially) facilitated by PIWI-interacting RNAs. NSC Ex/Mv might also physically interact with (pseudo)viral particles (Yu et al., 2020).

Synonyms

Murine neural stem/progenitor cell exosomes/microvesicles

 

Supporting references

Link Tested on Impact factor Notes Publication date
Innate and Adaptive Immunity of Murine Neural Stem Cell-Derived piRNA Exosomes/Microvesicles against Pseudotyped SARS-CoV-2 and HIV-Based Lentivirus
RNA Stem cells Cell-based therapy In vitro Mechanism Mixed substance Extracellular vesicles 		A549 cells; Calu3 cells; HepG2 cells; (ΔG-VSV) SARS-CoV-2 Spike pseudovirus 5.46

The cell products facilitated innate and adaptive antiviral responses against SARS-CoV-2 pseudovirus, which could have been enabled via PIWI-interacting RNAs. NSC Ex/Mv was also observed to directly interact with pseudoviral particles. 

 Dec/18/2020
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