Noscapine
An alkaloid.
General information
Noscapine is a non-narcotic alkaloid from Papaver somniferum. It displays antitussive and mild analgesic activity. Noscapine has been studies for potential antineoplastic activity, which could be due to its capability to inhibit mitosis via tubulin binding. This could in turn lead to tumour cell death (NCIt).
Noscapine on DrugBank
Noscapine on PubChem
Noscapine on Wikipedia
CN1CCC2=CC3=C(C(=C2[C@@H]1[C@@H]4C5=C(C(=C(C=C5)OC)OC)C(=O)O4)OC)OCO3
Supporting references
| Link | Tested on | Impact factor | Notes | Publication date |
|---|---|---|---|---|
|
Identification of an Antiviral Compound from the Pandemic Response Box that Efficiently Inhibits SARS-CoV-2 Infection In Vitro
Small molecule In vitro |
Vero E6 cells; Calu-3 cells | 4.15 | less potent than Remdesivir |
Nov/26/2020 |
|
Molecular binding mechanism and pharmacology comparative analysis of noscapine for repurposing against SARS-CoV-2 protease
Small molecule In silico |
in silico | 4.07 | Predicted to bind SARS-CoV-2 3C-like protease close to the binding pocket-3. |
Aug/06/2020 |
|
Antitussive noscapine and antiviral drug conjugates as arsenal against COVID-19: a comprehensive chemoinformatics analysis
3CLpro Small molecule In silico |
in silico | 3.31 | Conjugated with hydroxychloroquine is predicted to inhibit SARS-CoV-2 3C-like protease. |
Aug/20/2020 |
