NIM811
An experimental antiviral drug.
General information
NIM811 is a cyclophilin Inhibitor and a potential anti-hepatitis C virus drug (Ma et al., 2006).
NIM811 on DrugBank
NIM811 on PubChem
NIM811 on Wikipedia
Synonyms
9-(N-methyl-L-isoleucine)-cyclosporin A; N-methyl-4-isoleucine cyclosporin; (Melle-4)cyclosporin
CC[C@H]1C(=O)N(CC(=O)N([C@H](C(=O)N[C@H](C(=O)N([C@H](C(=O)N[C@H](C(=O)N[C@@H](C(=O)N([C@H](C(=O)N([C@H](C(=O)N([C@H](C(=O)N([C@H](C(=O)N1)[C@@H]([C@H](C)C/C=C/C)O)C)C(C)C)C)CC(C)C)C)CC(C)C)C)C)C)CC(C)C)C)C(C)C)[C@@H](C)CC)C)C
Supporting references
| Link | Tested on | Impact factor | Notes | Publication date |
|---|---|---|---|---|
|
Drug repurposing screens reveal cell-type-specific entry pathways and FDA-approved drugs active against SARS-Cov-2
Small molecule In vitro Screening |
Huh7.5 cells; Calu-3 cells; primary normal human bronchial epithelial cells; iPSC-derived AT2 cells; SARS-CoV-2 strain USA WA1/2020 | 8.11 | Inhibited SARS-CoV-2 replication in Huh7.5 cells and also in Calu-3 cells with an SI of >3. |
Mar/23/2021 |
AI-suggested references
| Link | Publication date |
|---|---|
|
[Role of cyclophilin A during coronavirus replication and the antiviral activities of its inhibitors].
|
Oct/12/2021 |
