Other substances

Nigellidine

An indazole-alkaloid.

Phase of research

Potential treatment - theoretical effect

How it helps

Antiviral

Drug status

Natural product

1
 Supporting references
0
 Contradictory references
3
 AI-suggested references
0
 Clinical trials

General information

Nigellidine on PubChem

 

Structure image - Nigellidine

CC1=CC(=O)C2=C(N3CCCCN3C2=C1)C4=CC=C(C=C4)O

Supporting references

Link Tested on Impact factor Notes Publication date
Active-site Molecular docking of Nigellidine with nucleocapsid- NSP2-MPro of COVID-19 and to human IL1R-IL6R and strong antioxidant role of Nigella-sativa in experimental rats
3CLpro IL-1 nsp2 Small molecule In silico 		in silico 3.38

Predicted affinity to the SARS-CoV-2 nsp2 RNA-binding protein, to the 3C-like protease and to the host's IL-1R.

 Sep/02/2020

AI-suggested references

Link Publication date
Nigellidine (Nigella sativa, black-cumin seed) docking to SARS CoV-2 nsp3 and host inflammatory proteins may inhibit viral replication/transcription and FAS-TNF death signal via TNFR 1/2 blocking.
Apr/28/2020
Identification of SARS-CoV-2 RNA-dependent RNA polymerase inhibitors from the major phytochemicals of Nigella sativa: An in silico approach.
Sep/08/2021
In silico Nigellidine (N. sativa) bind to viral spike/active-sites of ACE1/2, AT1/2 to prevent COVID-19 induced vaso-tumult/vascular-damage/comorbidity.
Mar/18/2021
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