Other substances

Neferine

A bis-benzylisoquinoline alkaloid.

Phase of research

Potential treatment - pre-clinical evidence

How it helps

Antiviral

Drug status

Natural product

1
 Supporting references
0
 Contradictory references
1
 AI-suggested references
0
 Clinical trials

General information

Neferine is a bis-benzylisoquinoline alkaloid. It has been reported to act as a calcium channel blocker and shown to possess anti-SARS-CoV-2 activity in vitro (He et al., 2021).

Neferine on PubChem

Synonyms

Neferin; SC185

 

Structure image - Neferine

CN1CCC2=CC(=C(C=C2[C@H]1CC3=CC=C(C=C3)OC)OC4=C(C=CC(=C4)C[C@@H]5C6=CC(=C(C=C6CCN5C)OC)OC)O)OC

Supporting references

Link Tested on Impact factor Notes Publication date
Identification of bis-benzylisoquinoline alkaloids as SARS-CoV-2 entry inhibitors from a library of natural products
Small molecule In vitro Mechanism 		in vitro binding assay; 293T-ACE2 cells; Calu-3 cells; A549 cells; Vero E6 cells; (HIV-1) SARS-CoV-2 Spike (D614/G614/B.1.1.7/B.1.351); SARS-CoV-2 live virus 13.49

Neferine inhibited lentiviral SARS-CoV-2 Spike-pseudotyped virus infection in 293T-ACE2 (EC50 of 0.95 μM or lower, SI >52), Calu-3 and A549 cells. It displayed efficacy also against pseudoviruses with Spike protein of G614, B.1.1.7, B.1.351, SARS, and MERS viruses/strains. The experimental findings suggest that the compound blocks coronavirus entry into host cells by inhibition of calcium ion channels. The compound was also shown to protect Vero E6 cells from SARS-CoV-2 live virus-induced cytopathogenic effect.

 Mar/23/2021

AI-suggested references

Link Publication date
Inhibitory effect on SARS-CoV-2 infection of neferine by blocking Ca2+ -dependent membrane fusion.
Jun/09/2021
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