Other substances

Nb203

A heterotrimeric anti-RBD (SARS-CoV-2 spike protein) nanobody.

Phase of research

Potential treatment - pre-clinical evidence

How it helps

Antiviral

Drug status

Experimental

1
 Supporting references
0
 Contradictory references
0
 AI-suggested references
0
 Clinical trials

General information

Nb203 is a homotrimeric construct made from a single-domain antibody (nanobody) identified in serum of a llama immunized by RBD of the SARS-CoV-2 spike protein. The nanobodody was selected based on its structure, RBD-binding and capacity to neutralize SARS-CoV-2 (pseudo)virus in vitro (Xiang et al., 2020). 

 

Supporting references

Link Tested on Impact factor Notes Publication date
Versatile and multivalent nanobodies efficiently neutralize SARS-CoV-2
Spike protein Biophysical assay In vitro Antibody 		in vitro biophysical assay; 293T-hsACE2 cells; Vero E6 cells; pseudotyped SARS-CoV-2 (Wuhan-Hu-1 strain); SARS-CoV-2 (Munich strain) 41.85

Manifests strong affinity to the SARS-CoV-2 spike protein RBD. Potently neutralizes the pseudotyped virus (IC50 4.1 pM) and live virus (IC50 5.4 pM).

 Nov/05/2020
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