Other substances

Naringenin

A trihydroxyflavanone.

Phase of research

Potential treatment - pre-clinical evidence

How it helps

Antiviral

Drug status

Natural product

Supporting references

Contradictory references

AI-suggested references

Clinical trials

General information

Naringenin on DrugBank
Naringenin on PubChem
Naringenin on Wikipedia

Synonyms

5,7-Dihydroxy-2-(4-hydroxyphenyl)chroman-4-one

C1C(OC2=CC(=CC(=C2C1=O)O)O)C3=CC=C(C=C3)O

Supporting references

Link	Tested on	Impact factor	Notes	Publication date
NARINGENIN IS A POWERFUL INHIBITOR OF SARS-CoV-2 INFECTION IN VITRO Small molecule In vitro	Vero E6 cells; SARS-CoV-2 hCoV-19/Italy/UniSR1/2020 isolate	5.89	Strong inhibition of SARS-CoV-2 (and HCoV229E and HCoVOC43) at safe concentrations in vitro.	Oct/20/2020

AI-suggested references

Link	Publication date
Investigation of the inhibitory activity of some dietary bioactive flavonoids against SARS-CoV-2 using molecular dynamics simulations and MM-PBSA calculations.	May/07/2020
Natural Agents Modulating ACE-2: A Review of Compounds with Potential against SARS-CoV-2 Infections.	Jan/19/2021
Molecular mechanisms revealed by network pharmacology of Xuebijing on the treatment of acute respiratory distress syndrome caused by novel coronavirus infection.	Jun/05/2020
In silico molecular docking studies of certain commercially available flavonoids as effective antiviral agents against spike glycoprotein of SARS-CoV-2.	Nov/18/2021
Identification of potential bioactive natural compounds from Indonesian medicinal plants against 3-chymotrypsin-like protease (3CLpro) of SARS-CoV-2: molecular docking, ADME/T, molecular dynamic simulations, and DFT analysis.	May/27/2020
Exploring the treatment of COVID-19 with Yinqiao powder based on network pharmacology	Jan/15/2021
In silico evaluation of Vitis amurensis Rupr. polyphenol compounds for their inhibition potency against CoVID-19 main enzymes Mpro and RdRp	Feb/28/2021
Repurposing of Some Natural Product Isolates as SARS-COV-2 Main Protease Inhibitors via In Vitro Cell Free and Cell-Based Antiviral Assessments and Molecular Modeling Approaches.	Mar/04/2021
Network pharmacology and molecular docking analyses on Lianhua Qingwen capsule indicate Akt1 is a potential target to treat and prevent COVID-19	Nov/03/2020
Naringenin, a flavanone with antiviral and anti-inflammatory effects: A promising treatment strategy against COVID-19.	Jul/02/2020
Biologically guided isolation and ADMET profile of new factor Xa inhibitors from Glycyrrhiza glabra roots using in vitro and in silico approaches.	Mar/09/2021
Mechanism of Dayuanyin in the treatment of coronavirus disease 2019 based on network pharmacology and molecular docking	Jun/12/2020
Therapeutic potential of phytoconstituents of edible fruits in combating emerging viral infections	Jul/08/2021
Using a System Pharmacology Method to Search for the Potential Targets and Pathways of Yinqiaosan against COVID-19	Mar/15/2022
The Discovery of Naringenin as Endolysosomal Two-Pore Channel Inhibitor and Its Emerging Role in SARS-CoV-2 Infection.	May/07/2021
Inhibitory effects of specific combination of natural compounds against SARS-CoV-2 and its Alpha, Beta, Gamma, Delta, Kappa, and Mu variants	Jan/21/2022
Structure-based drug designing for potential antiviral activity of selected natural products from Ayurveda against SARS-CoV-2 spike glycoprotein and its cellular receptor	May/24/2020
Citrus fruits are rich in flavonoids for immunoregulation and potential targeting ACE2	Feb/14/2022
Review on the potential action mechanisms of Chinese medicines in treating Coronavirus Disease 2019 (COVID-19)	May/21/2020
Flavonoids as potential phytotherapeutics to combat cytokine storm in SARS-CoV-2	Mar/29/2020

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