Other substances

Narciclasine

A lactam alkaloid.

Phase of research

Potential treatment - pre-clinical evidence

How it helps

Antiviral

Drug status

Natural product

1
 Supporting references
0
 Contradictory references
1
 AI-suggested references
0
 Clinical trials

General information

Narciclasine is a natural alkaloid that acts as an eukaryotic ribosomal peptidyl transferase inhibitor with antimitotic and potentially antineoplastic properties (Kornienko and Evidente, 2008).

Narciclasine on PubChem
Narciclasine on Wikipedia

Synonyms

Lycoricidinol

 

Structure image - Narciclasine

C1OC2=C(O1)C(=C3C(=C2)C4=C[C@@H]([C@H]([C@H]([C@@H]4NC3=O)O)O)O)O

Supporting references

Link Tested on Impact factor Notes Publication date
Enhancement of the IFN-β-induced host signature informs repurposed drugs for COVID-19
Small molecule In vitro In silico 		in silico; Vero E6 cells; SARS-CoV-2 strain hCoV-19/Taiwan/NTU13/2020

Cell treatment results in transcriptional response with high degree of similarity to interferon beta treatment. Potently inhibits SARS-CoV-2 infection in vitro (IC50 = 16.5. nM) with selectivity index of 4.56.

 Dec/02/2020

AI-suggested references

Link Publication date
Enhancement of the IFN-beta-induced host signature informs repurposed drugs for COVID-19.
Dec/02/2020
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