Other substances

Naproxen

Phase of research

Potential treatment - pre-clinical evidence

How it helps

Antiviral

Drug status

Used to treat other disease

Supporting references

Contradictory references

AI-suggested references

Clinical trials

Supporting references

Link	Tested on	Impact factor	Notes	Publication date
Broad-spectrum antiviral activity of naproxen: from Influenza A to SARS-CoV-2 Coronavirus Preprint	reconstituted human airway epithelia			May/01/2020

AI-suggested references

Link	Publication date
Antiviral Properties of the NSAID Drug Naproxen Targeting the Nucleoprotein of SARS-CoV-2 Coronavirus	Jan/30/2022
Efficacy of naproxen in the management of patients hospitalized with COVID-19 infection: A randomized, double-blind, placebo-controlled, clinical trial	Mar/13/2021
Transcriptome network analyses in human coronavirus infections suggest a rational use of immunomodulatory drugs for COVID-19 therapy	Jan/20/2021
The efficacy of corticosteroids therapy in patients with moderate to severe SARS-CoV-2 infection: a multicenter, randomized, open-label trial	Dec/30/2020
Repurposing existing drugs: identification of SARS-CoV-2 3C-like protease inhibitors	Jan/13/2021
The clinical value of two combination regimens in the Management of Patients Suffering from Covid-19 pneumonia: a single centered, retrospective, observational study	Jun/19/2020

Clinical trials

ID	Title	Status	Phase	Start date	Completion date
NCT04325633	Efficacy of Addition of Naproxen in the Treatment of Critically Ill Patients Hospitalized for COVID-19 Infection	Terminated	Phase 3	Apr/24/2020	Dec/15/2020
Alternative id - APHP200387 Interventions - Drug: 1: Naproxen\|Drug: 2: Standard of care Study type - Interventional Study results - No Results Available Locations - Réanimation médico-chirurgicale, Avicenne Hospital, Bobigny, France\|Urgences, Avicenne Hospital, Bobigny, France Study designs - Allocation: Randomized\|Intervention Model: Parallel Assignment\|Masking: None (Open Label)\|Primary Purpose: Treatment Enrollment - 30 Age - 18 Years and older (Adult, Older Adult) Outcome measures - Mortality all causes at day30\|Number of days alive free of mechanical ventilation\|Number of days alive outside\|Number of days alive outside hospital\|Maximal changes in Sofa score\|Time to negativation of virus titer in the nasopharyngeal aspirate (NPA)