Other substances

Moxidectin

An antiparasitic macrocyclic lactone.

Phase of research

Potential treatment - pre-clinical evidence

How it helps

Antiviral

Drug status

Used to treat other disease

1
 Supporting references
0
 Contradictory references
1
 AI-suggested references
0
 Clinical trials

General information

Moxidectin is a macrocyclic lactone with antiparasitic activity. It binds nematode neuronal and pharyngeal muscle glutamate-gated chloride channels, gamma-aminobutyric acid (GABA) receptors, and/or ATP-binding cassette (ABC) transporters. This results in parasite’s muscle paralysis and decreased fertility (NCIt).

Moxidectin on DrugBank
Moxidectin on PubChem
Moxidectin on Wikipedia


Marketed as

MOXIDECTIN

 

Structure image - Moxidectin

C[C@@H]\1C/C(=C/C[C@@H]2C[C@@H](C[C@@]3(O2)C/C(=N\OC)/[C@@H]([C@H](O3)/C(=C/C(C)C)/C)C)OC(=O)[C@@H]4C=C([C@H]([C@@H]5[C@]4(/C(=C/C=C1)/CO5)O)O)C)/C

Supporting references

Link Tested on Impact factor Notes Publication date
Identification of existing pharmaceuticals and herbal medicines as inhibitors of SARS-CoV-2 infection
3CLpro PapainLpro Enzyme assay Animal model In vitro In silico 		in silico; in vitro enzyme assay; Vero E6 cells; golden Syrian hamsters; SARS-CoV-2 clinical isolate hCoV-19/Taiwan/4/2020 9.41

Inhibited SARS-CoV-2 infection in Vero E6 cells but displayed high cytotoxicity.

 Jan/15/2021

AI-suggested references

Link Publication date
Moxidectin and Ivermectin Inhibit SARS-CoV-2 Replication in Vero E6 Cells but Not in Human Primary Bronchial Epithelial Cells
May/01/2021
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