Other substances

Monensin

A polyether ionophore antibiotic.

Phase of research

Potential treatment - pre-clinical evidence

How it helps

Antiviral

Drug status

Used to treat other disease

2
 Supporting references
0
 Contradictory references
2
 AI-suggested references
0
 Clinical trials

General information

Monensin is a polyether ionophore antibiotic used as an animal feed additive. Besides antiprotozoal activity, it acts as a growth promoter (ChEBI).

Monensin on DrugBank
Monensin on PubChem
Monensin on Wikipedia

Synonyms

Monensin A

 

Structure image - Monensin

CC[C@]1(CC[C@@H](O1)[C@@]2(CC[C@@]3(O2)C[C@@H]([C@H]([C@H](O3)[C@@H](C)[C@H]([C@H](C)C(=O)O)OC)C)O)C)[C@H]4[C@H](C[C@@H](O4)[C@@H]5[C@H](C[C@H]([C@@](O5)(CO)O)C)C)C

Supporting references

Link Tested on Impact factor Notes Publication date
Identification of Potent and Safe Antiviral Therapeutic Candidates Against SARS-CoV-2
Small molecule In vitro Screening 		Vero cells 5.09

Monensin sodium salt inhibits SARS-CoV-2 in Vero cells with a high selectivity index.

 Nov/25/2020
Ionophore antibiotic X-206 is a potent inhibitor of SARS-CoV-2 infection in vitro
Small molecule In vitro 		Vero E6 cells; Vero E6-hTMPRSS2 cells; Calu-3 cells 4.10

Inhibited SARS-CoV-2 in cell culture.

 Nov/25/2020

AI-suggested references

Link Publication date
Screening for natural and derived bio-active compounds in preclinical and clinical studies: One of the frontlines of fighting the coronaviruses pandemic.
Aug/29/2020
Published anti-SARS-CoV-2 in vitro hits share common mechanisms of action that synergize with antivirals
Nov/07/2021
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