Other substances

MLN-4760

An experimental ACE2 inhibitor.

Phase of research

Potential treatment - theoretical effect

How it helps

Antiviral

Drug status

Experimental

1
 Supporting references
0
 Contradictory references
10
 AI-suggested references
0
 Clinical trials

General information

MLN-4760 on PubChem

Synonyms

(S,S)-2-{1-Carboxy-2-[3-(3,5-dichloro-benzyl)-3H-imidazol-4-YL]-ethylamino}-4-methyl-pentanoic acid

 

Structure image - MLN-4760

CC(C)C[C@@H](C(=O)O)N[C@@H](CC1=CN=CN1CC2=CC(=CC(=C2)Cl)Cl)C(=O)O

Supporting references

Link Tested on Impact factor Notes Publication date
An Active Site Inhibitor Induces Conformational Penalties for ACE2 Recognition by the Spike Protein of SARS-CoV-2
Spike protein ACE2 Small molecule In silico 		in silico 2.86

Computationally modelled to impede SARS-CoV-2 Spike protein-host ACE2 receptor interaction.

 Mar/03/2021

AI-suggested references

Link Publication date
Molecular modelling identification of phytocompounds from selected African botanicals as promising therapeutics against druggable human host cell targets of SARS-CoV-2.
Jun/11/2021
Angiotensin System Modulations in Spontaneously Hypertensive Rats and Consequences on Erythrocyte Properties; Action of MLN-4760 and Zofenopril.
Dec/14/2021
The interaction of the severe acute respiratory syndrome coronavirus 2 spike protein with drug-inhibited angiotensin converting enzyme 2 studied by molecular dynamics simulation.
Jan/07/2021
Molecular modeling of the interaction of ligands with ACE2-SARS-CoV-2 spike protein complex
Oct/07/2021
Investigation of potential inhibitor properties of ethanolic propolis extracts against ACE-II receptors for COVID-19 treatment by molecular docking study
Mar/10/2021
Vascular Effects of Low-Dose ACE2 Inhibitor MLN-4760:Benefit or Detriment in Essential Hypertension?
Sep/26/2021
Angiotensin II Promotes SARS-CoV-2 Infection via Upregulation of ACE2 in Human Bronchial Cells
May/04/2022
In Silico Comparison of Separate or Combinatorial Effects of Potential Inhibitors of the SARS-CoV-2 Binding Site of ACE2
Jun/30/2021
Mechanism of Ligand Recognition by Human ACE2 Receptor
May/17/2021
Design and synthesis of pyrazolone-based compounds as potent blockers of SARS-CoV-2 viral entry into the host cells.
May/13/2021
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