Other substances

Mitoxantrone

An anthracenedione antibiotic.

Phase of research

Potential treatment - pre-clinical evidence

How it helps

Antiviral

Drug status

Used to treat other disease

Supporting references

Contradictory references

AI-suggested references

Clinical trials

General information

Mitoxantrone is an anthracenedione antibiotic with antineoplastic properties. It acts as a DNA intercalating agent which introduces crosslinks. It also impedes topoisomerase II activity (NCIt).

Mitoxantrone on DrugBank
Mitoxantrone on PubChem
Mitoxantrone on Wikipedia

Marketed as

MITOXANTRONE HYDROCHLORIDE

C1=CC(=C2C(=C1NCCNCCO)C(=O)C3=C(C=CC(=C3C2=O)O)O)NCCNCCO

Supporting references

Link	Tested on	Impact factor	Notes	Publication date
Molecular docking and simulation studies on SARS-CoV-2 Mpro reveals Mitoxantrone, Leucovorin, Birinapant, and Dynasore as potent drugs against COVID-19 3CLpro Small molecule In silico	in silico	3.31	Predicted to inhibit SARS-CoV-2 3C-like protease.	Aug/20/2020
Heparan sulfate assists SARS-CoV-2 in cell entry and can be targeted by approved drugs in vitro Polysaccharide Small molecule In vitro	ACE2-GFP HEK293T cells; Calu-3 cells; Vero E6 cells; SARS-CoV-2 pseudotyped particles	6.26	Inhibits SARS-CoV-2 pseudovirus with selectivity index of > 100 in ACE2-GFP HEK293T cells. The experimental results suggest that it binds to cell membranes. It did not alleviate cytopathic effect in Vero E6 cells-based assay, however.	Nov/04/2020

AI-suggested references

Link	Publication date
Clinical course and outcome of SARS-CoV-2 infection in multiple sclerosis patients treated with disease-modifying therapies - the Polish experience.	Feb/28/2021
SARS-CoV-2 nucleocapsid protein interacts with immunoregulators and stress granules and phase separates to form liquid droplets	Nov/22/2021
Mitoxantrone dihydrochloride, an FDA approved drug, binds with SARS-CoV-2 NSP1 C-terminal.	Feb/16/2022
Mitoxantrone modulates a heparan sulfate-spike complex to inhibit SARS-CoV-2 infection	Apr/15/2022

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