Mitoxantrone
An anthracenedione antibiotic.
General information
Mitoxantrone is an anthracenedione antibiotic with antineoplastic properties. It acts as a DNA intercalating agent which introduces crosslinks. It also impedes topoisomerase II activity (NCIt).
Mitoxantrone on DrugBank
Mitoxantrone on PubChem
Mitoxantrone on Wikipedia
Marketed as
MITOXANTRONE HYDROCHLORIDE
![Structure image - Mitoxantrone](/data/images/681.png)
C1=CC(=C2C(=C1NCCNCCO)C(=O)C3=C(C=CC(=C3C2=O)O)O)NCCNCCO
Supporting references
Link | Tested on | Impact factor | Notes | Publication date |
---|---|---|---|---|
Molecular docking and simulation studies on SARS-CoV-2 Mpro reveals Mitoxantrone, Leucovorin, Birinapant, and Dynasore as potent drugs against COVID-19
3CLpro Small molecule In silico |
in silico | 3.31 | Predicted to inhibit SARS-CoV-2 3C-like protease. |
Aug/20/2020 |
Heparan sulfate assists SARS-CoV-2 in cell entry and can be targeted by approved drugs in vitro
Polysaccharide Small molecule In vitro |
ACE2-GFP HEK293T cells; Calu-3 cells; Vero E6 cells; SARS-CoV-2 pseudotyped particles | 6.26 | Inhibits SARS-CoV-2 pseudovirus with selectivity index of > 100 in ACE2-GFP HEK293T cells. The experimental results suggest that it binds to cell membranes. It did not alleviate cytopathic effect in Vero E6 cells-based assay, however. |
Nov/04/2020 |