Other substances

Menadione

A 1,4-naphthoquinones nutraceutical.

Phase of research

Potential treatment - pre-clinical evidence

How it helps

Antiviral

Drug status

Used to treat other disease

2
 Supporting references
0
 Contradictory references
0
 AI-suggested references
0
 Clinical trials

General information

Menadione is a synthetic 1,4-naphthoquinone compound used as a nutritional supplement and in the treatment of hypoprothrombinemia (ChEBI). It can be converted to active vitamin K2 in vivo (DrugBank).

Menadione on PubChem
Menadione on Wikipedia

Synonyms

Vitamin K3

Marketed as

LIBAVIT-K; SYNKAVITE

 

Structure image - Menadione

CC1=CC(=O)C2=CC=CC=C2C1=O


 

Supporting references

Link Tested on Impact factor Notes Publication date
Molecules inhibit the enzyme activity of 3-chymotrypsin-like cysteine protease of SARS-CoV-2 virus: the experimental and theory studies
Preprint 		in vitro May/29/2020
Identification of Vitamin K3 and its analogues as covalent inhibitors of SARS-CoV-2 3CLpro
3CLpro Small molecule Enzyme assay In vitro In silico 		in silico; in vitro enzyme assay 5.16

The compound inhibited SARS-CoV-2 3C-like protease with an IC50 of ca. 4.78 μM in vitro.

 Apr/24/2021
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