Other substances

Memantine

An N-methyl-D-aspartate (NMDA) receptor antagonist.

Phase of research

Potential treatment - pre-clinical evidence

How it helps

Antiviral

Drug status

Used to treat other disease

Supporting references

Contradictory references

AI-suggested references

Clinical trials

General information

Memantine is a drug approved for Alzheimer’s disease treatment. It acts as a N-methyl-D-aspartate (NMDA) receptor antagonist, by which it blocks the effects of glutamate (DrugBank).

Memantine on PubChem
Memantine on Wikipedia

Marketed as

MEMANTINE HYDROCHLORIDE; NAMENDA (MEMANTINE HYDROCHLORIDE)

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Supporting references

Link	Tested on	Impact factor	Notes	Publication date
SARS-CoV-2 E protein is a potential ion channel that can be inhibited by Gliclazide and Memantine Envelope protein Small molecule In vitro	In vitro ion channel assay	2.99	Blocks the SARS-CoV-2 E protein ion channel in vitro.	Jun/20/2020

AI-suggested references

Link	Publication date
Calcium Channel Blockers: A Possible Potential Therapeutic Strategy for the Treatment of Alzheimer's Dementia Patients with SARS-CoV-2 Infection.	Jul/14/2020
Treatment of Catatonia with Asenapine in a Patient with Schizotypal Personality Disorder, Psychotic Depression and Septic Shock from SARSCoV- 2 - A Case Report.	Feb/27/2021
Safety, efficacy, and tolerability of memantine for cognitive and adaptive outcome measures in adolescents and young adults with Down syndrome: a randomised, double-blind, placebo-controlled phase 2 trial.	Dec/24/2021
Potential for the Repurposing of Adamantane Antivirals for COVID-19	Apr/29/2020
Efficacy of Ion-Channel Inhibitors Amantadine, Memantine and Rimantadine for the Treatment of SARS-CoV-2 In Vitro	Mar/17/2021
Potential role of memantine in the prevention and treatment of COVID-19: its antagonism of nicotinic acetylcholine receptors and beyond	Jun/05/2021
Adamantanes might be protective from COVID-19 in patients with neurological diseases: multiple sclerosis, parkinsonism and cognitive impairment	Oct/12/2021
Anti-Inflammatory Effects of Amantadine and Memantine: Possible Therapeutics for the Treatment of Covid-19?	Nov/09/2020

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