mAb8
An anti-Spike receptor binding motif (SARS-CoV-2) antibody.
General information
mAb8 is a monoclonal antibody selected for its affinity for receptor-binding motif (RBM) of SARS-CoV-2 Spike protein. It inhibited RBM-ACE2 interaction and decreased GMâCSF secretion by human peripheral blood mononuclear cells, murine macrophage-like cells, and hACE2-expressing mice stimulated by RBM in vitro (Qiang et al., 2021).
Supporting references
Link | Tested on | Impact factor | Notes | Publication date |
---|---|---|---|---|
Monoclonal antibodies capable of binding SARS‐CoV‐2 spike protein receptor‐binding motif specifically prevent GM‐CSF induction
Spike protein ACE2 Animal model In vitro Antibody |
RAW 264.7 cells; human peripheral blood mononuclear cells; K18‐hACE2 mice | 3.76 | The antibody displayed dose-dependent binding of receptor binding motif (RBM) of SARS-CoV-2 Spike protein in vitro (KD of 17.4 nM). It competitively inhibited the RBM-ACE2 interaction and reduced RBM-stimulated secretion of GM-CSF by primary human peripheral blood mononuclear cells, murine macrophage-like cells, and in hACE2 mice. This activity was hypothesized to prevent cytokine storm development. |
Mar/24/2021 |