Other substances

MAb362

A human IgA monoclonal antibody binding the SARS-CoV-2 spike protein.

Phase of research

Potential treatment - pre-clinical evidence

How it helps

Antiviral

Drug status

Experimental

1
 Supporting references
0
 Contradictory references
0
 AI-suggested references
0
 Clinical trials

General information

MAb362 is an IgA antibody originating in a human gene expressed by mice and produced by hybridomas. It blocks SARS-CoV-2 spike-ACE2 interaction (Ejemel et al., 2020).

 

Supporting references

Link Tested on Impact factor Notes Publication date
A cross-reactive human IgA monoclonal antibody blocks SARS-CoV-2 spike-ACE2 interaction
Spike protein In vitro Antibody 		Vero E6 cells 12.12

The IgA antibody originating in a human gene expressed by mice and produced by hybridomas was identified in an ELISA screening. The antibody bound to the SARS-CoV-2 spike protein S1 and RBD domains, neutralized preudotyped SARS-CoV-2 virus and protected cells from pseudovirus infection.

 Aug/21/2020
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