Lycorine
An alkaloid.
General information
A bioactive pyrrolidine alkaloid, which has been shown to act also as a non-nucleoside RNA-dependent RNA polymerase inhibitor (Jin et al., 2020).
Lycorine on PubChem
Lycorine on Wikipedia
Synonyms
Amarylline; Galanthidine; Narcissine
C1CN2CC3=CC4=C(C=C3[C@H]5[C@H]2C1=C[C@@H]([C@H]5O)O)OCO4
Supporting references
| Link | Tested on | Impact factor | Notes | Publication date |
|---|---|---|---|---|
|
Lycorine, a non-nucleoside RNA dependent RNA polymerase inhibitor, as potential treatment for emerging coronavirus infections
RdRpol Small molecule In vitro |
in silico; Vero cells; SARS-CoV-2 strain βCoV/KOR/KCDC03/2020 | 4.27 | Inhibited SARS-CoV-2 with IC50 of ca. 0.878 μM in vitro. It was predicted to act via SARS-CoV-2 RNA-dependent RNA polymerase (RdRpol) inhibition (based on docking simulations and MERS-CoV RdRpol inhibition in vitro). |
Dec/16/2020 |
