Other substances

Luteolin

A flavonoid.

Phase of research

Potential treatment - theoretical effect

How it helps

Antiviral

Drug status

Natural product

Supporting references

Contradictory references

AI-suggested references

Clinical trials

General information

Luteolin on PubChem

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Supporting references

Link	Tested on	Impact factor	Notes	Publication date
Identification of potential inhibitors of SARS-CoV-2 main protease and spike receptor from 10 important spices through structure-based virtual screening and molecular dynamic study Spike protein 3CLpro Small molecule In silico Screening	in silico	3.22	Predicted to bind to the SARS-CoV-2 spike protein.	Sep/18/2020
Network pharmacology for the identification of phytochemicals in traditional Chinese medicine for COVID-19 that may regulate interleukin-6 IL-6 Small molecule In silico	in silico	2.94	Predicted to downregulate IL-6.	Nov/04/2020
In silico screening of potential anti–COVID-19 bioactive natural constituents from food sources by molecular docking 3CLpro ACE2 Small molecule In silico	in silico	3.64	Predicted to be effective as an anti-COVID-19 dietary supplement.	Nov/07/2020
A network pharmacology based approach for predicting active ingredients and potential mechanism of Lianhuaqingwen capsule in treating COVID-19 3CLpro Small molecule In silico	in silico	2.52	Predicted to bind SARS-CoV-2 3C-like protease.	Feb/24/2021

AI-suggested references

Link	Publication date
Theoretical Study of the Molecular Mechanism of Maxingyigan Decoction Against COVID-19: Network Pharmacology-based Strategy.	Oct/08/2020
Natural Products: A Rich Source of Antiviral Drug Lead Candidates for the Management of COVID-19.	Nov/21/2020
Therapeutic mechanism of Xiaoqinglong decoction against COVID-19 based on network pharmacology and molecular docking technology.	Feb/03/2022
Natural Agents Modulating ACE-2: A Review of Compounds with Potential against SARS-CoV-2 Infections.	Jan/19/2021
Flavonoids as potential therapeutics against novel coronavirus disease-2019 (nCOVID-19).	Mar/08/2021
Can Antimalarial Phytochemicals be a Possible Cure for COVID-19? Molecular Docking Studies of Some Phytochemicals to SARS-CoV-2 3C-like Protease.	Jan/27/2021
Study on the Mechanism of treating COVID-19 with Shenqi Wan based on Network Pharmacology.	May/17/2021
An in-silico approach to identify the potential hot spots in SARS-CoV-2 spike RBD to block the interaction with ACE2 receptor.	May/13/2020
In silico molecular docking studies of certain commercially available flavonoids as effective antiviral agents against spike glycoprotein of SARS-CoV-2.	Nov/18/2021
Identification of potential phytochemicals from Citrus Limon against main protease of SARS-CoV-2: molecular docking, molecular dynamic simulations and quantum computations.	Jul/19/2021
Randomized clinical trial "olfactory dysfunction after COVID-19: olfactory rehabilitation therapy vs. intervention treatment with Palmitoylethanolamide and Luteolin": preliminary results.	Sep/30/2021
Exploring the Potential Mechanism of Shufeng Jiedu Capsule for Treating COVID-19 by Comprehensive Network Pharmacological Approaches and Molecular Docking Validation.	Mar/11/2020
Identification of potential bioactive natural compounds from Indonesian medicinal plants against 3-chymotrypsin-like protease (3CLpro) of SARS-CoV-2: molecular docking, ADME/T, molecular dynamic simulations, and DFT analysis.	May/27/2020
In silico screening and covalent binding of phytochemicals of Ocimum sanctum against SARS-CoV-2 (COVID 19) main protease.	Nov/25/2021
In Silico Studies Reveal Antiviral Effects of Traditional Indian Spices on COVID-19.	Dec/29/2020
Ultramicronized Palmitoylethanolamide and Luteolin Supplement Combined with Olfactory Training to Treat Post-COVID-19 Olfactory Impairment: A Multi-Center Double-Blinded Randomized Placebo-Controlled Clinical Trial.	Apr/23/2022
Computational Analysis Illustrates the Mechanism of Qingfei Paidu Decoction in Blocking the Transition of COVID-19 Patients from Mild to Severe Stage	May/13/2021
Exploring the treatment of COVID-19 with Yinqiao powder based on network pharmacology	Jan/15/2021
In Silico and In Vitro Identification of Pan-Coronaviral Main Protease Inhibitors from a Large Natural Product Library	Mar/15/2022
In silico study of potential anti-SARS cell entry phytoligands from Phlomis aurea: a promising avenue for prophylaxis	Mar/24/2022
Luteolin and abyssinone II as potential inhibitors of SARS-CoV-2: an in silico molecular modeling approach in battling the COVID-19 outbreak	Aug/30/2021
In Silico computational screening of Kabasura Kudineer - Official Siddha Formulation and JACOM against SARS-CoV-2 spike protein	May/29/2020
A Review of Medicinal Plants with Antiviral Activity Available in Bangladesh and Mechanistic Insight Into Their Bioactive Metabolites on SARS-CoV-2, HIV and HBV.	Nov/08/2021
Ugonin J Acts as a SARS-CoV-2 3C-like Protease Inhibitor and Exhibits Anti-inflammatory Properties.	Aug/26/2021
New tale on LianHuaQingWen: IL6R/IL6/IL6ST complex is a potential target for COVID-19 treatment	Nov/03/2021
In silico detection of inhibitor potential of Passiflora compounds against SARS-Cov-2(Covid-19) main protease by using molecular docking and dynamic analyses.	May/04/2021
Therapeutic mechanism of Toujie Quwen granules in COVID-19 based on network pharmacology.	Sep/24/2020
Virtual Screening and Molecular Docking to Study the Mechanism of Chinese Medicines in the Treatment of Coronavirus Infection	Feb/24/2022
Yindan Jiedu granules exhibit anti-inflammatory effect in patients with novel Coronavirus disease (COVID-19) by suppressing the NF-kappaB signaling pathway.	Oct/01/2021
Antiviral Activity of Vitis vinifera Leaf Extract against SARS-CoV-2 and HSV-1	May/28/2020
Investigation of potential inhibitor properties of ethanolic propolis extracts against ACE-II receptors for COVID-19 treatment by molecular docking study	Mar/10/2021
Molecular docking analysis of potential compounds from an Indian medicinal soup "kabasura kudineer" extract with IL-6	May/31/2021
In Silico Screening of Natural Products Isolated from Mexican Herbal Medicines against COVID-19	Mar/15/2021
Network pharmacology and molecular docking analyses on Lianhua Qingwen capsule indicate Akt1 is a potential target to treat and prevent COVID-19	Nov/03/2020
Chemical profiling and unraveling of anti-COVID-19 biomarkers of red sage (Lantana camara L.) cultivars using UPLC-MS/MS coupled to chemometric analysis, in vitro study and molecular docking	Feb/10/2022
Analysis of the mechanism of Shufeng Jiedu capsule prevention and treatment for COVID-19 by network pharmacology tools.	Oct/30/2020
Traditional Chinese medicine network pharmacology study on exploring the mechanism of Xuebijing Injection in the treatment of coronavirus disease 2019	Dec/29/2020
Molecular docking analysis of SARS-CoV-2 linked RNA dependent RNA polymerase (RdRp) with compounds from Plectranthus amboinicus	May/30/2022
Analysis of the active components and mechanism of Shufeng Jiedu capsule against COVID-19 based on network pharmacology and molecular docking	Jan/15/2022
Computer-Aided Analysis of Multiple SARS-CoV-2 Therapeutic Targets: Identification of Potent Molecules from African Medicinal Plants.	Sep/12/2020
Structure-based virtual screening and molecular dynamics of phytochemicals derived from Saudi medicinal plants to identify potential COVID-19 therapeutics.	Aug/09/2020
Pathomechanisms, therapeutic targets and potent inhibitors of some beta-coronaviruses from bench-to-bedside.	May/28/2021
Structure-based virtual screening suggests inhibitors of 3-Chymotrypsin-Like Protease of SARS-CoV-2 from Vernonia amygdalina and Occinum gratissimum.	Jul/21/2021
Different compounds against Angiotensin-Converting Enzyme 2 (ACE2) receptor potentially containing the infectivity of SARS-CoV-2: an in silico study	Mar/05/2022
Potential role of medicinal plants and their constituents in the mitigation of SARS-CoV-2: identifying related therapeutic targets using network pharmacology and molecular docking analyses	Oct/13/2020
Prediction of Anti-COVID 19 Therapeutic Power of Medicinal Moroccan Plants Using Molecular Docking	Apr/08/2021
Identifying the molecular targets and mechanisms of xuebijing injection for the treatment of COVID-19 via network pharmacology and molecular docking	Mar/06/2021
Molecular Docking Studies on the Anti-viral Effects of Compounds From Kabasura Kudineer on SARS-CoV-2 3CLpro.	Dec/23/2020
Therapeutic potential of medicinal plants against COVID-19: The role of antiviral medicinal metabolites.	Dec/11/2020
Roles of flavonoids against coronavirus infection.	Jul/28/2020
Luteolin Potentially Treating Prostate Cancer and COVID-19 Analyzed by the Bioinformatics Approach: Clinical Findings and Drug Targets	Jun/22/2020
Using a System Pharmacology Method to Search for the Potential Targets and Pathways of Yinqiaosan against COVID-19	Mar/15/2022
Tripartite Combination of Candidate Pandemic Mitigation Agents: Vitamin D, Quercetin, and Estradiol Manifest Properties of Medicinal Agents for Targeted Mitigation of the COVID-19 Pandemic Defined by Genomics-Guided Tracing of SARS-CoV-2 Targets in Human	May/21/2020
Phytocompounds as potential inhibitors of SARS-CoV-2 Mpro and PLpro through computational studies	Feb/25/2022
Luteolin: a blocker of SARS-CoV-2 cell entry based on relaxed complex scheme, molecular dynamics simulation, and metadynamics.	Jul/08/2021
Flavonoids are promising safe therapy against COVID-19.	May/22/2021
Structure-based drug designing for potential antiviral activity of selected natural products from Ayurveda against SARS-CoV-2 spike glycoprotein and its cellular receptor	May/24/2020
Review on the potential action mechanisms of Chinese medicines in treating Coronavirus Disease 2019 (COVID-19)	May/21/2020
Exploration of the Mechanism of Lianhua Qingwen in Treating Influenza Virus Pneumonia and New Coronavirus Pneumonia with the Concept of "Different Diseases with the Same Treatment" Based on Network Pharmacology	May/25/2021
Flavonoids as potential phytotherapeutics to combat cytokine storm in SARS-CoV-2	Mar/29/2020
Newly designed analogues from SARS-CoV inhibitors mimicking the druggable properties against SARS-CoV-2 and its novel variants	Nov/30/2020
Computational screening of antagonists against the SARS-CoV-2 (COVID-19) coronavirus by molecular docking	May/08/2020

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