Other substances

Loperamide

A piperidine anti-diarrheal.

Phase of research

Potential treatment - pre-clinical evidence

How it helps

Antiviral

Drug status

Used to treat other disease

2
 Supporting references
0
 Contradictory references
0
 AI-suggested references
0
 Clinical trials

General information

Loperamide is an anti-diarrheal compound that acts by decreasing gastro-intestinal secretion and motility. It might bind to opioid receptors in the intestinal mucosa (NCIt).

Loperamide on DrugBank
Loperamide on PubChem
Loperamide on Wikipedia

Marketed as

DIMOR; FORTASEC; IMODIUM; KAOPECTATE II; LOPEDIUM; LOPEDIUM EXPRESS; LOPEX; MAALOX ANTI-DIARRHEAL; PEPTO DIARRHEA CONTROL

 

Structure image - Loperamide

CN(C)C(=O)C(CCN1CCC(CC1)(C2=CC=C(C=C2)Cl)O)(C3=CC=CC=C3)C4=CC=CC=C4

Supporting references

Link Tested on Impact factor Notes Publication date
Comparative analysis of antiviral efficacy of FDA-approved drugs against SARS-CoV-2 in human lung cells: Nafamostat is the most potent antiviral drug candidate
Preprint 		Calu-3 human airway epithelial cells

Hydrochloride salt; comparable IC50 value between Calu-3 and VERO E6 cells

 May/12/2020
Kinetic characterization and inhibitor screening for the proteases leading to identification of drugs against SARS-CoV-2
3CLpro PapainLpro Small molecule Enzyme assay In vitro 		in vitro enzyme assay; Vero E6 cells 4.92

The compound inhibited the SARS-CoV-2 Papain-like protease in a dose-dependent manner in vitro. It protected Vero E6 cells from viral infection with EC50 of 11.4 μM and SI of 4.9. It was determined to be active at the post-entry stage of infection.

 Feb/01/2021
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