Other substances

Litronesib

A kinesin-related motor protein inhibitor

Phase of research

Potential treatment - pre-clinical evidence

How it helps

Antiviral

Drug status

Experimental

1
 Supporting references
0
 Contradictory references
0
 AI-suggested references
0
 Clinical trials

General information

Litronesib is an inhibitor of Eg5, which is a motor protein related to kinesin. Eg5 has an essential role during mitosis; thus, the drug is studied as a potential antineoplastic agent (NCIt).

Litronesib on DrugBank
Litronesib on PubChem

 

Structure image - Litronesib

CCNCCS(=O)(=O)NC[C@@]1(N(N=C(S1)NC(=O)C(C)(C)C)C(=O)C(C)(C)C)C2=CC=CC=C2


 

Supporting references

Link Tested on Impact factor Notes Publication date
Blockers of the SARS-CoV-2 3a Channel Identified by Targeted Drug Repurposing
Small molecule In vitro 		in vitro bacteria-based assay 3.82

Displayed inhibitory activity against the potential ion channel ORF3a of SARS-CoV-2 in a bacterial model assay.

 Mar/23/2021
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