Levothyroxine
A synthetic version of the thyroid hormone thyroxine.
General information
Levothyroxine is a synthetic thyroxine (T4) (a thyroid hormone) isomer. It is involved in multiple cellular processes (NCIt). It used as a supplement in patients with insufficient thyroid gland T4 or triiodothyronine (T3) secretion (DrugBank).
Levothyroxine on PubChem
Levothyroxine on Wikipedia
Synonyms
L-thyroxine
Marketed as
ELTROXIN; EUTHYROX; EUTIROX; LETROX; LEVAXIN; LEVO-T; LEVOTEC; LEVOTHROID; LEVOTHYROX; LEVOTHROXINE SODIUM; LEVOXYL; NOVOTHYROX; OROXINE; SYNTHROID; TIROSINT; THYRAX; UNITHROID
C1=C(C=C(C(=C1I)OC2=CC(=C(C(=C2)I)O)I)I)C[C@@H](C(=O)O)N
Supporting references
| Link | Tested on | Impact factor | Notes | Publication date |
|---|---|---|---|---|
|
Drugs Repurposing Using QSAR, Docking and Molecular Dynamics for Possible Inhibitors of the SARS-CoV-2 Mpro Protease
3CLpro Small molecule In silico |
in silico | 3.27 | Predicted to inhibit the SARS-CoV-2 3C-like protease. |
Nov/06/2020 |
|
Kinetic characterization and inhibitor screening for the proteases leading to identification of drugs against SARS-CoV-2
3CLpro PapainLpro Small molecule Enzyme assay In vitro |
in vitro enzyme assay; Vero E6 cells | 4.92 | The compound inhibited the SARS-CoV-2 3C-like protease and Papain-like protease in a dose-dependent manner in vitro. It protected Vero E6 cells from viral infection with EC50 of 7 μM and SI of >14.3. It was determined to be active at the pre-entry stage of infection. |
Feb/01/2021 |
