Other substances

Leucovorin

A folate analogue.

Phase of research

Potential treatment - theoretical effect

How it helps

Antiviral

Drug status

Used to treat other disease

2
 Supporting references
0
 Contradictory references
1
 AI-suggested references
0
 Clinical trials

General information

Leucovorin on PubChem

Synonyms

Leucal

Marketed as

KHAPZORY; LEUCOVORIN CALCIUM; FUSILEV (LEVOLEUCOVORIN CALCIUM); LEVOLEUCOVORIN CALCIUM

 

Structure image - Leucovorin

C1C(N(C2=C(N1)N=C(NC2=O)N)C=O)CNC3=CC=C(C=C3)C(=O)N[C@@H](CCC(=O)O)C(=O)O

Supporting references

Link Tested on Impact factor Notes Publication date
Molecular docking and simulation studies on SARS-CoV-2 Mpro reveals Mitoxantrone, Leucovorin, Birinapant, and Dynasore as potent drugs against COVID-19
3CLpro Small molecule In silico 		in silico 3.31

Predicted to inhibit SARS-CoV-2 3C-like protease.

 Aug/20/2020
Computational molecular docking and virtual screening revealed promising SARS-CoV-2 drugs
3CLpro PapainLpro RdRpol Small molecule In silico 		in silico

Predicted to inhibit SARS-CoV-2 RNA-dependent RNA polymerase.

 Jan/18/2021

AI-suggested references

Link Publication date
The folate antagonist methotrexate diminishes replication of the coronavirus SARS-CoV-2 and enhances the antiviral efficacy of remdesivir in cell culture models
Apr/19/2021
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