An amino acid derivative.

Phase of research

Potential treatment - pre-clinical evidence

How it helps


Drug status

Natural product

Supporting references
Contradictory references
AI-suggested references
Clinical trials

General information

L-carnitine is an amino acid derivative which facilitates long-chain fatty acid entry into mitochondria. Fatty acids are thus used as an energy substrate in most of human tissues (NCIt).

L-Carnitine on PubChem
L-Carnitine on DrugBank
L-Carnitine on Wikipedia


Levocarnitine; (R)-Carnitine; (-)-Carnitine; Karnitin



Supporting references

Link Tested on Impact factor Notes Publication date
L-Carnitine Tartrate Downregulates the ACE2 Receptor and Limits SARS-CoV-2 Infection
Small molecule In vitro
Vero E6 cells; Calu-3 cells; SARS-CoV-2 isolate LSPQ1; rats and healthy humans (host dependency factors levels’ assessment only) 5.72

In the form of CarnipureTM tartrate. Decreased ACE2, TMPRSS2 and Furin levels in rodent and human tissues following exercise-induced inflammation. The preparation decreased susceptibility of Calu-3 cells to SARS-CoV-2 infection.


AI-suggested references

Clinical trials

ID Title Status Phase Start date Completion date
NCT04623619 Efficacy and Safety of Acetyl L-Carnitine in COVID-19 Patients With Mild-to-Moderate Disease Not yet recruiting Not Applicable Dec/15/2020 Jul/31/2021
  • Alternative id - 20201109
  • Interventions - Dietary Supplement: Acetyl L-Carnitine
  • Study type - Interventional
  • Study results - No Results Available
  • Locations -
  • Study designs - Allocation: Randomized|Intervention Model: Parallel Assignment|Masking: None (Open Label)|Primary Purpose: Treatment
  • Enrollment - 100
  • Age - 18 Years and older   (Adult, Older Adult)
  • Outcome measures - In-hospital mortality|C reactive protein (CRP) levels|IL-6 levels|D-dimer levels|Hospital stay|Duration of positive PCR swab