L-Carnitine
An amino acid derivative.
General information
L-carnitine is an amino acid derivative which facilitates long-chain fatty acid entry into mitochondria. Fatty acids are thus used as an energy substrate in most of human tissues (NCIt).
L-Carnitine on PubChem
L-Carnitine on DrugBank
L-Carnitine on Wikipedia
Synonyms
Levocarnitine; (R)-Carnitine; (-)-Carnitine; Karnitin
C[N+](C)(C)C[C@@H](CC(=O)[O-])O
Supporting references
Link | Tested on | Impact factor | Notes | Publication date |
---|---|---|---|---|
L-Carnitine Tartrate Downregulates the ACE2 Receptor and Limits SARS-CoV-2 Infection
Small molecule In vitro |
Vero E6 cells; Calu-3 cells; SARS-CoV-2 isolate LSPQ1; rats and healthy humans (host dependency factors levels’ assessment only) | 5.72 | In the form of CarnipureTM tartrate. Decreased ACE2, TMPRSS2 and Furin levels in rodent and human tissues following exercise-induced inflammation. The preparation decreased susceptibility of Calu-3 cells to SARS-CoV-2 infection. |
Apr/14/2021 |
AI-suggested references
Clinical trials
ID | Title | Status | Phase | Start date | Completion date |
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NCT04623619 | Efficacy and Safety of Acetyl L-Carnitine in COVID-19 Patients With Mild-to-Moderate Disease | Not yet recruiting | Not Applicable | Dec/15/2020 | Jul/31/2021 |
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