Kaempferol

A tetrahydroxyflavone.

Phase of research

Potential treatment - pre-clinical evidence

How it helps

Antiviral

Drug status

Natural product

3
Supporting references
0
Contradictory references
54
AI-suggested references
0
Clinical trials

General information

Kaempferol is a tetrahydroxyflavone. Due to its antioxidant properties it is considered for cancer treatment. Kaempferol also displays antibacterial activity (ChEBI).

Kaempferol on DrugBank
Kaempferol on PubChem
Kaempferol on Wikipedia


Synonyms

Kaempherol; Kempferol; Robigenin

 

Structure image - Kaempferol

C1=CC(=CC=C1C2=C(C(=O)C3=C(C=C(C=C3O2)O)O)O)O


Supporting references

Link Tested on Impact factor Notes Publication date
An in-silico evaluation of different bioactive molecules of tea for their inhibition potency against non structural protein-15 of SARS-CoV-2
nsp15 Small molecule In silico
in silico 6.31

Predicted to inhibit the SARS-CoV-2 endoribonuclease (nsp15).

Dec/28/2020
In silico and in vitro evaluation of kaempferol as a potential inhibitor of the SARS‐CoV‐2 main protease (3CLpro)
3CLpro Small molecule In vitro In silico
in silico; Vero E6 cells; SARS‐CoV‐2 live virus (GeneBank MT123290.1) 4.09

The compound was computationally predicted to bind the SARS-CoV-2 3C-like protease and inhibited SARS-CoV-2-induced cytopathic effect in Vero E6 cells with an estimated IC50 of ca. 34.5 μM.

Jan/15/2021
A network pharmacology based approach for predicting active ingredients and potential mechanism of Lianhuaqingwen capsule in treating COVID-19
3CLpro Small molecule In silico
in silico 2.52

Predicted to bind SARS-CoV-2 3C-like protease.

Feb/24/2021

AI-suggested references

Link Publication date
Combined molecular docking and dynamics simulations studies of natural compounds as potent inhibitors against SARS-CoV-2 main protease.
Jul/27/2021
Molecular modelling identification of phytocompounds from selected African botanicals as promising therapeutics against druggable human host cell targets of SARS-CoV-2.
Jun/11/2021
Screening of potential bio-molecules from Moringa olifera against SARS-CoV-2 main protease using computational approaches.
Jun/21/2021
Therapeutic mechanism of Xiaoqinglong decoction against COVID-19 based on network pharmacology and molecular docking technology.
Feb/03/2022
Flavonoids as potential therapeutics against novel coronavirus disease-2019 (nCOVID-19).
Mar/08/2021
In silico evaluation of COVID-19 main protease interactions with honeybee natural products for discovery of high potential antiviral compounds.
Sep/09/2021
Study on the Mechanism of treating COVID-19 with Shenqi Wan based on Network Pharmacology.
May/17/2021
Molecular Docking Studies of Bioactive Nicotiflorin against 6W63 Novel Coronavirus 2019 (COVID-19).
Jun/01/2021
Mechanistic Aspects of Medicinal Plants and Secondary Metabolites against Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2).
Jul/07/2021
Structural Bioinformatics Used to Predict the Protein Targets of Remdesivir and Flavones in SARS-CoV-2 Infection.
Oct/08/2021
Exploring the Potential Mechanism of Shufeng Jiedu Capsule for Treating COVID-19 by Comprehensive Network Pharmacological Approaches and Molecular Docking Validation.
Mar/11/2020
Evaluation of the effects of chlorhexidine and several flavonoids as antiviral purposes on SARS-CoV-2 main protease: molecular docking, molecular dynamics simulation studies.
Feb/08/2022
Natural Compounds as Inhibitors of SARS-CoV-2 Main Protease (3CLpro): A Molecular Docking and Simulation Approach to Combat COVID-19.
Nov/18/2020
Insights into the Antimicrobial, Antioxidant, Anti-SARS-CoV-2 and Cytotoxic Activities of Pistacia lentiscus Bark and Phytochemical Profile; In Silico and In Vitro Study.
May/09/2022
Potentiality of Moringa oleifera against SARS-CoV-2: identified by a rational computer aided drug design method.
Mar/15/2021
MD simulation and MM/PBSA identifies phytochemicals as bifunctional inhibitors of SARS-CoV-2.
Aug/27/2021
Computational Analysis Illustrates the Mechanism of Qingfei Paidu Decoction in Blocking the Transition of COVID-19 Patients from Mild to Severe Stage
May/13/2021
Potential of Plant Bioactive Compounds as SARS-CoV-2 Main Protease (Mpro) and Spike (S) Glycoprotein Inhibitors: A Molecular Docking Study.
Dec/23/2020
In silico docking analysis revealed the potential of phytochemicals present in Phyllanthus amarus and Andrographis paniculata, used in Ayurveda medicine in inhibiting SARS-CoV-2.
Jan/11/2021
A Review of Medicinal Plants with Antiviral Activity Available in Bangladesh and Mechanistic Insight Into Their Bioactive Metabolites on SARS-CoV-2, HIV and HBV.
Nov/08/2021
Multimodal Identification by Transcriptomics and Multiscale Bioassays of Active Components in Xuanfeibaidu Formula to Suppress Macrophage-Mediated Immune Response.
Nov/15/2021
Ugonin J Acts as a SARS-CoV-2 3C-like Protease Inhibitor and Exhibits Anti-inflammatory Properties.
Aug/26/2021
Therapeutic mechanism of Toujie Quwen granules in COVID-19 based on network pharmacology.
Sep/24/2020
nCOV-19 peptides mass fingerprinting identification, binding, and blocking of inhibitors flavonoids and anthraquinone of Moringa oleifera and hydroxychloroquine
Jun/01/2022
In silico analysis of quranic and prophetic medicinals plants for the treatment of infectious viral diseases including corona virus
Feb/23/2021
Yindan Jiedu granules exhibit anti-inflammatory effect in patients with novel Coronavirus disease (COVID-19) by suppressing the NF-kappaB signaling pathway.
Oct/01/2021
Chinese herbal compounds against SARS-CoV-2: Puerarin and quercetin impair the binding of viral S-protein to ACE2 receptor.
Nov/11/2020
Virtual screenings of the bioactive constituents of tea, prickly chaff, catechu, lemon, black pepper, and synthetic compounds with the main protease (Mpro) and human angiotensin-converting enzyme 2 (ACE 2) of SARS-CoV-2.
Jun/15/2021
A review of natural products, their effects on SARS-CoV-2 and their utility as lead compounds in the discovery of drugs for the treatment of COVID-19
Nov/28/2020
Antiviral Activity of Vitis vinifera Leaf Extract against SARS-CoV-2 and HSV-1
May/28/2020
In Silico Screening of Natural Products Isolated from Mexican Herbal Medicines against COVID-19
Mar/15/2021
Network pharmacology and molecular docking analyses on Lianhua Qingwen capsule indicate Akt1 is a potential target to treat and prevent COVID-19
Nov/03/2020
Analysis of the mechanism of Shufeng Jiedu capsule prevention and treatment for COVID-19 by network pharmacology tools.
Oct/30/2020
Analysis of the active components and mechanism of Shufeng Jiedu capsule against COVID-19 based on network pharmacology and molecular docking
Jan/15/2022
Flavonoids from Siparuna cristata as Potential Inhibitors of SARS-CoV-2 Replication.
Jul/20/2021
Epicatechin is a promising novel inhibitor of SARS-CoV-2 entry by disrupting interactions between angiotensin-converting enzyme type 2 and the viral receptor binding domain: A computational/simulation study.
Dec/17/2021
Network pharmacology-based predictions of active components and pharmacological mechanisms of Artemisia annua L. for the treatment of the novel Corona virus disease 2019 (COVID-19)
Mar/03/2022
Structure-based virtual screening and molecular dynamics of phytochemicals derived from Saudi medicinal plants to identify potential COVID-19 therapeutics.
Aug/09/2020
Molecular Docking and ADMET Prediction of Natural Compounds towards SARS Spike Glycoprotein-Human Angiotensin-Converting Enzyme 2 and SARS-CoV-2 Main Protease.
Sep/01/2021
In silico targeting SARS-CoV-2 spike protein and main protease by biochemical compounds
Sep/22/2021
Indian Ethnomedicinal Phytochemicals as Promising Inhibitors of RNA-Binding Domain of SARS-CoV-2 Nucleocapsid Phosphoprotein: An In Silico Study
Jul/02/2021
Flavonoid glycosides and their putative human metabolites as potential inhibitors of the SARS-CoV-2 main protease (Mpro) and RNA-dependent RNA polymerase (RdRp)
Sep/30/2020
Potential role of medicinal plants and their constituents in the mitigation of SARS-CoV-2: identifying related therapeutic targets using network pharmacology and molecular docking analyses
Oct/13/2020
Phytoconstituents, In Vitro Anti-Infective Activity of Buddleja indica Lam., and In Silico Evaluation of its SARS-CoV-2 Inhibitory Potential
Apr/12/2021
A molecular docking study of SARS-CoV-2 main protease against phytochemicals of Boerhavia diffusa Linn. for novel COVID-19 drug discovery.
Mar/18/2021
Mechanism of Dayuanyin in the treatment of coronavirus disease 2019 based on network pharmacology and molecular docking
Jun/12/2020
In silico screening of potent bioactive compounds from honeybee products against COVID-19 target enzymes
May/02/2021
Using a System Pharmacology Method to Search for the Potential Targets and Pathways of Yinqiaosan against COVID-19
Mar/15/2022
Network pharmacology and molecular docking analysis on mechanisms of Tibetan Hongjingtian (Rhodiola crenulata) in the treatment of COVID-19
Jul/28/2021
Natural Compounds Inhibit SARS-CoV-2 nsp13 Unwinding and ATPase Enzyme Activities.
Apr/01/2022
Potential mechanisms of Chinese Herbal Medicine that implicated in the treatment of COVID-19 related renal injury.
Aug/10/2020
Review on the potential action mechanisms of Chinese medicines in treating Coronavirus Disease 2019 (COVID-19)
May/21/2020
Inhibition of drug-metabolizing enzymes by Jingyin granules: implications of herb-drug interactions in antiviral therapy
Jun/28/2021
Flavonols and dihydroflavonols inhibit the main protease activity of SARS-CoV-2 and the replication of human coronavirus 229E.
Apr/12/2022