Ipomoeassin F
A macrocyclic cytotoxin.
General information
Ipomoeassin F was found to be a potent selective inhibitor of co-translational protein import to endoplasmic reticulum (ER) mediated by Sec61, which has been shown to play a role in the life cycle of several viruses. It thus inhibits membrane insertion of SARS-CoV-2 Spike and ORF8-encoded proteins and also the host's ACE2 receptor integration into ER (O’Keefe et al., 2021 and thereby cited).
Ipomoeassin F on PubChem
Synonyms
Ipomoeassin-F
CCCCCC1CCCCCCC(=O)CCC(=O)OCC2C(C(C(C(O2)OC3C(C(C(OC3O1)C)OC(=O)C)O)O)OC(=O)/C(=C/C)/C)OC(=O)/C=C/C4=CC=CC=C4
Supporting references
| Link | Tested on | Impact factor | Notes | Publication date |
|---|---|---|---|---|
|
Ipomoeassin-F inhibits the in vitro biogenesis of the SARS-CoV-2 spike protein and its host cell membrane receptor
Spike protein ACE2 ORF8 Small molecule Enzyme assay In vitro |
in vitro enzyme assay; HeLa cells | 4.57 | The compound inhibited membrane insertion of SARS-CoV-2 Spike protein and ORF8-encoded protein and also the host's ACE2 receptor ER integration. |
Jan/19/2021 |
