Interferon gamma

A cytokine.

Phase of research

Potential treatment - pre-clinical evidence

How it helps

Antiviral

Drug status

Natural product

1
Supporting references
0
Contradictory references
237
AI-suggested references
2
Clinical trials

General information

Interferon gamma (IFN-γ) is a type I inflammatory cytokine with antiviral properties, antitumor activity, and immunoregulatory functions. It is involved in JAK/STAT, MAPK, and PI3-Kinase signaling pathways (DrugBank).

IFN-γ on Wikipedia


Synonyms

IFN-γ

 


Supporting references

Link Tested on Impact factor Notes Publication date
Antiviral Activity of Type I, II, and III Interferons Counterbalances ACE2 Inducibility and Restricts SARS-CoV-2
Protein factor In vitro
Calu-3 cells; primary human bronchial epithelial cells 6.78

Despite capability of ACE2 upregulation, the interferon inhibited SARS-CoV-2 in a dose-dependent manner.

Sep/10/2020

AI-suggested references

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Tocilizumab-Induced Unexpected Increase of Several Inflammatory Cytokines in Critically Ill COVID-19 Patients: The Anti-Inflammatory Side of IL-6.
Jan/27/2022
The JAK inhibitor ruxolitinib abrogates immune hepatitis instigated by concanavalin A in mice.
Dec/21/2021
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May/24/2022
Epitope based peptide vaccine against SARS-COV2: an immune-informatics approach.
Feb/01/2022
Biotin Functionalized Self-Assembled Peptide Nanofiber as an Adjuvant for Immunomodulatory Response.
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Antiviral effect of fufang yinhua jiedu (FFYH) granules against influenza A virus through regulating the inflammatory responses by TLR7/MyD88 signaling pathway.
May/23/2020
Resveratrol-mediated attenuation of superantigen-driven acute respiratory distress syndrome is mediated by microbiota in the lungs and gut.
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Immune Responses to a Single Dose of the AZD1222/Covishield Vaccine at 16 Weeks in Individuals in Sri Lanka.
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A rational design of a multi-epitope vaccine against SARS-CoV-2 which accounts for the glycan shield of the spike glycoprotein.
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Cutting Edge: T Cell Responses to B.1.1.529 (Omicron) SARS-CoV-2 Variant Induced by COVID-19 Infection and/or mRNA Vaccination Are Largely Preserved.
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Anti-Inflammatory Effects of Immunostimulation in Patients with COVID-19 Pneumonia.
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Predictive factors of a viral neutralizing humoral response after a third dose of COVID-19 mRNA vaccine in kidney transplant recipients.
Jul/22/2021
Identification of HLA-A2 restricted CD8+ T cell epitopes in SARS-CoV-2 structural proteins.
Jul/07/2021
Induction of Th1 and Th2 in the protection against SARS-CoV-2 through mucosal delivery of an adenovirus vaccine expressing an engineered spike protein.
Dec/17/2021
mRNA Vaccine Protects against Zika Virus.
Dec/10/2021
[Interferon gamma in the treatment of patients with moderate COVID-19].
Jan/06/2022
Status of Humoral and Cellular Immune Responses within 12 Months following CoronaVac Vaccination against COVID-19.
May/19/2022
Analysis of the humoral and cellular immune response after a full course of BNT162b2 anti-SARS-CoV-2 vaccine in cancer patients treated with PD-1/PD-L1 inhibitors with or without chemotherapy: an update after 6 months of follow-up.
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Feb/13/2022
Computational profiling of natural compounds as promising inhibitors against the spike proteins of SARS-CoV-2 wild-type and the variants of concern, viral cell-entry process, and cytokine storm in COVID-19.
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Immunogenicity and safety after the third dose of BNT162b2 anti-SARS-CoV-2 vaccine in patients with solid tumors on active treatment: a prospective cohort study.
Mar/11/2022
Antiinflammatory potential of nano-curcumin as an alternative therapeutic agent for the treatment of mild-to-moderate hospitalized COVID-19 patients in a placebo-controlled clinical trial.
Jan/17/2022
[Therapeutic effect of Compound Qinlan Oral Liquid on treating combining disease with syndrome of human coronavirus pneumonia with pestilence attacking lung syndrome].
Feb/07/2022
Factors Associated With Serological Response to SARS-CoV-2 Vaccination in Patients With Multiple Sclerosis Treated With Rituximab.
May/02/2022
Nucleocapsid protein of SARS-CoV-2 is a potential target for developing new generation of vaccine.
May/09/2022
Cutting Edge: Circulating Exosomes with COVID Spike Protein Are Induced by BNT162b2 (Pfizer-BioNTech) Vaccination prior to Development of Antibodies: A Novel Mechanism for Immune Activation by mRNA Vaccines.
Nov/20/2020
Differential Cytokine Responses in Hospitalized COVID-19 Patients Limit Efficacy of Remdesivir
Jun/28/2021
Aluminum Nanoparticles Acting as a Pulmonary Vaccine Adjuvant-Delivery System (VADS) Able to Safely Elicit Robust Systemic and Mucosal Immunity
Feb/24/2021
Identification of Novel T-Cell Epitopes on Infectious Bronchitis Virus N Protein and Development of a Multi-epitope Vaccine.
Aug/10/2021
Pharmacological mechanism of immunomodulatory agents for the treatment of severe cases of COVID-19 infection
Jun/25/2020
An anti-CD6 antibody for the treatment of COVID-19 patients with cytokine-release syndrome: report of three cases
Jan/05/2021
Young infants exhibit robust functional antibody responses and restrained IFN-gamma production to SARS-CoV-2.
Jun/09/2021
SARS-CoV-2-specific antibody and T-cell responses 1 year after infection in people recovered from COVID-19: a longitudinal cohort study
Mar/23/2022
Induction of humoral and cellular immune responses to COVID-19 mRNA and vector vaccines: A prospective cohort study in Bulgarian healthcare workers
Jan/18/2022
Oral subunit SARS-CoV-2 vaccine induces systemic neutralizing IgG, IgA and cellular immune responses and can boost neutralizing antibody responses primed by an injected vaccine
Jan/19/2022
B- and T-Cell Responses After SARS-CoV-2 Vaccination in Patients With Multiple Sclerosis Receiving Disease Modifying Therapies: Immunological Patterns and Clinical Implications
Jan/17/2022
Analysis of the molecular mechanism of Pudilan (PDL) treatment for COVID-19 by network pharmacology tools
May/30/2020
Impact of Moderna mRNA-1273 Booster Vaccine on Fully Vaccinated High-Risk Chronic Dialysis Patients after Loss of Humoral Response
Apr/11/2022
Durable T-cellular and humoral responses in SARS-CoV-2 hospitalized and community patients
Aug/30/2020
mRNA COVID-19 vaccine booster fosters B- and T-cell responses in immunocompromised patients
Feb/15/2022
Cytotoxic T lymphocytes targeting a conserved SARS-CoV-2 spike epitope are efficient serial killers
Jun/30/2020
Development of an mRNA-LNP Vaccine against SARS-CoV-2: Evaluation of Immune Response in Mouse and Rhesus Macaque.
Sep/10/2021
Myricetin Inhibits SARS-CoV-2 Viral Replication by Targeting Mpro and Ameliorates Pulmonary Inflammation.
Jun/17/2021
The temporal course of T- and B-cell-responses to vaccination with BNT162b2 and mRNA-1273
Sep/20/2021
B Cell Depletion and SARS-CoV-2 Vaccine Responses in Neuroimmunologic Patients
Mar/01/2022
Peptides Derived From S and N Proteins of Severe Acute Respiratory Syndrome Coronavirus 2 Induce T Cell Responses: A Proof of Concept for T Cell Vaccines
Sep/24/2021
Evaluation of Cell-Penetrating Peptides as Mucosal Immune Enhancers for Nasal Vaccination
Apr/20/2020
Cell therapy in patients with COVID-19 using Wharton's jelly mesenchymal stem cells: a phase 1 clinical trial
Jul/16/2021
Development of Potent Cellular and Humoral Immune Responses in Long-Term Hemodialysis Patients After 1273-mRNA SARS-CoV-2 Vaccination
May/23/2020
Acute exercise increases immune responses to SARS CoV-2 in a previously infected man.
Sep/22/2021
CMV-associated T cell and NK cell terminal differentiation does not affect immunogenicity of ChAdOx1 vaccination
Nov/30/2021
Characterization of SARS-CoV-2-Specific Humoral and Cellular Immune Responses Induced by Inactivated COVID-19 Vaccines in a Real-World Setting
Jul/11/2020
The preparation of N-IgY targeting SARS-CoV-2 and its immunomodulation to IFN-gamma production in vitro.
May/19/2021
SARS-CoV-2 vaccination in rituximab-treated patients: B cells promote humoral immune responses in the presence of T-cell-mediated immunity
Jul/20/2021
Nafamostat reduces systemic inflammation in TLR7-mediated virus-like illness
Jan/06/2022
Humoral and cellular immunogenicity of SARS-CoV-2 vaccines in chronic lymphocytic leukemia: a prospective cohort study
Sep/15/2021
A prospective observational study for justification, safety, and efficacy of a third dose of mRNA vaccine in patients receiving maintenance hemodialysis
Nov/29/2021
Ultraviolet-A light reduces cellular cytokine release from human endotracheal cells infected with Coronavirus.
Jul/24/2021
SARS-CoV-2-specific T-cell responses after COVID-19 recovery in patients with rheumatic diseases on immunosuppressive therapy.
Nov/07/2021
Synthetic SARS-CoV-2 Spike-Based DNA Vaccine Elicits Robust and Long-Lasting Th1 Humoral and Cellular Immunity in Mice
May/22/2020
A Single Dose of Self-Transcribing and Replicating RNA Based SARS-CoV-2 Vaccine Produces Protective Adaptive Immunity In Mice.
Apr/05/2021
A single dose of SARS-CoV-2 FINLAY-FR-1A vaccine enhances neutralization response in COVID-19 convalescents, with a very good safety profile: An open-label phase 1 clinical trial
Jan/12/2022
B and T cell immune responses elicited by the Comirnaty COVID-19 vaccine in nursing home residents
Jun/24/2021
The ROMANOV study found impaired humoral and cellular immune responses to SARSCov-2 mRNA vaccine in virus unexposed patients receiving maintenance hemodialysis.
May/31/2021
Integrated hepatic single-cell RNA sequencing and untargeted metabolomics reveals the immune and metabolic modulation of Qing-Fei-Pai-Du decoction in mice with coronavirus-induced pneumonia.
Jan/02/2022
SARS-CoV-2 specific memory T cell epitopes identified in COVID-19-recovered subjects.
Jul/27/2021
Intranasal Coronavirus SARS-CoV-2 Immunization with Lipid Adjuvants Provides Systemic and Mucosal Immune Response against SARS-CoV-2 S1 Spike and Nucleocapsid Protein
Mar/25/2022
"Small" Intestinal Immunopathology Plays a "Big" Role in Lethal Cytokine Release Syndrome, and Its Modulation by Interferon-gamma, IL-17A, and a Janus Kinase Inhibitor
Jun/26/2020
Comparative Immunomodulatory Evaluation of the Receptor Binding Domain of the SARS-CoV-2 Spike Protein; a Potential Vaccine Candidate Which Imparts Potent Humoral and Th1 Type Immune Response in a Mouse Model.
May/24/2021
MSC-NTF (NurOwn ) exosomes: a novel therapeutic modality in the mouse LPS-induced ARDS model
Jan/19/2021
Applying high throughput and comprehensive immunoinformatics approaches to design a trivalent subunit vaccine for induction of immune response against emerging human coronaviruses SARS-CoV, MERS-CoV and SARS-CoV-2
Jan/29/2021
Neutralizing Antibodies and Cellular Immune Responses Against SARS-CoV-2 Sustained One and a Half Years After Natural Infection
Mar/12/2021
Qingwenzhike Prescription Alleviates Acute Lung Injury Induced by LPS via Inhibiting TLR4/NF-kB Pathway and NLRP3 Inflammasome Activation
Dec/31/2021
Prompt Reduction in CRP, IL-6, IFN-gamma, IP-10, and MCP-1 and a Relatively Low Basal Ratio of Ferritin/CRP Is Possibly Associated With the Efficacy of Tocilizumab Monotherapy in Severely to Critically Ill Patients With COVID-19
Sep/23/2021
Evaluation of the Immune Response Induced by CoronaVac 28-Day Schedule Vaccination in a Healthy Population Group
Jan/31/2022
Rapid and sustained decline in CXCL-10 (IP-10) annotates clinical outcomes following TNFalpha-antagonist therapy in hospitalized patients with severe and critical COVID-19 respiratory failure.
Jun/25/2021
Localized and Systemic Immune Responses against SARS-CoV-2 Following Mucosal Immunization
Feb/06/2021
Safety and immunogenicity of a Recombinant Stabilized Prefusion SARS-CoV-2 Spike Protein Vaccine (MVC-COV1901) Adjuvanted with CpG 1018 and Aluminum Hydroxide in healthy adults: A Phase 1, dose-escalation study.
Jun/26/2021
Possible therapeutic effects of Nigella sativa and its thymoquinone on COVID-19
Feb/07/2022
Safety and immunogenicity of the SARS-CoV-2 ARCoV mRNA vaccine in Chinese adults: a randomised, double-blind, placebo-controlled, phase 1 trial
Jan/07/2022
Kinetics of Severity Biomarkers and Immunological Features of Methylprednisolone Therapy for Severe COVID-19 Patients
Mar/08/2022
Weak immunogenicity of SARS-CoV-2 vaccine in patients with hematologic malignancies
Aug/10/2021
Immunogenicity Studies of Plant-Produced SARS-CoV-2 Receptor Binding Domain-Based Subunit Vaccine Candidate with Different Adjuvant Formulations.
Jul/05/2021
Th1 skewed immune response of whole virion inactivated SARS CoV 2 vaccine and its safety evaluation.
Mar/10/2021
COVID-19 convalescent plasma composition and immunological effects in severe patients.
Jan/22/2021
Improvement of clinical outcome, laboratory findings and inflammatory cytokines levels using plasmapheresis therapy in severe COVID-19 cases.
Oct/26/2021
Heterologous Immunity Between SARS-CoV-2 and Pathogenic Bacteria
May/11/2021
Humoral and cellular immune responses to SARS CoV-2 vaccination in Persons with Multiple Sclerosis and NMOSD patients receiving immunomodulatory treatments
Oct/30/2020
Safety, reactogenicity, and immunogenicity of homologous and heterologous prime-boost immunisation with ChAdOx1 nCoV-19 and BNT162b2: a prospective cohort study.
Aug/13/2021
Efficacy and Safety of Ergoferon in Children from 6 Months to 6 Years Old with Acute Respiratory Viral Infections in Contemporary Outpatient Practice: A Multicenter, Double-Blind, Placebo-Controlled Randomized Trial.
Nov/15/2021
Beneficial effect of Indigo Naturalis on acute lung injury induced by influenza A virus.
Dec/21/2020
Off-the-shelf CAR natural killer cells secreting IL-15 target spike in treating COVID-19
Nov/27/2020
Three Specific Potential Epitopes That Could Be Recognized by T Cells of Convalescent COVID-19 Patients Were Identified From Spike Protein
Jul/30/2021
Distinct immune cell dynamics correlate with the immunogenicity and reactogenicity of SARS-CoV-2 mRNA vaccine.
Apr/22/2022
Prime-boost vaccination of mice and rhesus macaques with two novel adenovirus vectored COVID-19 vaccine candidates
May/18/2021
Structural Basis for Designing Multiepitope Vaccines Against COVID-19 Infection: In Silico Vaccine Design and Validation.
Jun/19/2020
The Effects of Insulin-Like Growth Factor I and BTP-2 on Acute Lung Injury.
May/15/2021
Discordant humoral and T cell immune responses to SARS-CoV-2 vaccination in people with multiple sclerosis on anti-CD20 therapy
May/12/2021
T cell-mediated response to SARS-CoV-2 in liver transplant recipients with prior COVID-19
Oct/30/2020
Humoral and Cellular Responses to SARS-CoV-2 in Convalescent COVID-19 Patients With Multiple Sclerosis
Feb/01/2022
A Self-Biomineralized Novel Adenovirus Vectored COVID-19 Vaccine for Boosting Immunization of Mice
Sep/28/2021
Immunogenicity of Pfizer-BioNTech COVID-19 vaccine in patients with inborn errors of immunity.
Jun/01/2021
Low Doses of Radiation Increase the Immunosuppressive Profile of Lung Macrophages During Viral Infection and Pneumonia.
Mar/13/2021
Coordinated cellular and humoral immune responses after two-dose SARS-CoV2 mRNA vaccination in liver transplant recipients
Nov/17/2021
Bee Venom:A Potential Complementary Medicine Candidate for SARS-CoV-2 Infections
Oct/30/2020
SARS-CoV-2 Vaccine Responses in Individuals with Antibody Deficiency: Findings from the COV-AD Study
Apr/14/2022
Humoral and Cellular Responses to COVID-19 Vaccines in SARS-CoV-2 Infection-Naive and -Recovered Korean Individuals
Feb/18/2022
Adaptive immune responses in vaccinated patients with symptomatic SARS-CoV-2 Alpha infection
Aug/28/2021
Persistence of Antibody and Cellular Immune Responses in COVID-19 patients over Nine Months after Infection
Jul/14/2021
SARS-CoV2 wild type and mutant specific humoral and T cell immunity is superior after vaccination than after natural infection
Jan/29/2022
Can emapalumab be life saving for refractory, recurrent, and progressive cytokine storm caused by COVID-19, which is resistant to anakinra, tocilizumab, and Janus kinase inhibitors
Jun/26/2021
Immunogenicity of repeat COVID-19 mRNA vaccinations in a patient with myasthenia gravis receiving mycophenolate, prednisone, and eculizumab.
Aug/19/2021
Circulating CD4 T cells elicited by endemic coronaviruses display vast disparities in abundance and functional potential linked to both antigen specificity and age
Aug/10/2021
Elucidating the Pivotal Immunomodulatory and Anti-Inflammatory Potentials of Chloroquine and Hydroxychloroquine
Jun/12/2021
Recombinant human interleukin-7 reverses T cell exhaustion ex vivo in critically ill COVID-19 patients
Mar/05/2022
The Pro-Inflammatory Chemokines CXCL9, CXCL10 and CXCL11 Are Upregulated Following SARS-CoV-2 Infection in an AKT-Dependent Manner.
Jun/03/2021
Identification of HLA-A*02:01-Restricted Candidate Epitopes Derived from the Nonstructural Polyprotein 1a of SARS-CoV-2 That May Be Natural Targets of CD8+ T Cell Recognition In Vivo
Dec/02/2020
Exploration of surface glycoprotein to design multi-epitope vaccine for the prevention of Covid-19.
Oct/04/2020
SARS-CoV-2 mutations in MHC-I-restricted epitopes evade CD8+ T cell responses
Sep/25/2021
Humoral and cellular immune response elicited by mRNA vaccination against SARS-CoV-2 in people living with HIV (PLWH) receiving antiretroviral therapy (ART) according with current CD4 T-lymphocyte count
Mar/04/2022
TNF-alpha+ CD4+ T cells dominate the SARS-CoV-2 specific T cell response in COVID-19 outpatients and are associated with durable antibodies.
May/03/2022
SARS-CoV-2 T-Cell Responses in Allogeneic Hematopoietic Stem Cell Recipients following Two Doses of BNT162b2 mRNA Vaccine
Mar/14/2022
Safety and immunogenicity of the ChAdOx1 nCoV-19 (AZD1222) vaccine against SARS-CoV-2 in HIV infection: a single-arm substudy of a phase 2/3 clinical trial
Nov/15/2021
Effects of Short-Term Corticosteroid Use on Reactogenicity and Immunogenicity of the First Dose of ChAdOx1 nCoV-19 Vaccine
Sep/22/2021
Innate Immune Responses of Vaccinees Determine Early Neutralizing Antibody Production After ChAdOx1nCoV-19 Vaccination
Jan/25/2022
E4orf1 Suppresses E1B-Deleted Adenovirus Vaccine-Induced Immune Responses
Feb/15/2022
Predictors and Dynamics of the Humoral and Cellular Immune Response to SARS-CoV-2 mRNA Vaccines in Hemodialysis Patients: A Multicenter Observational Study.
Dec/30/2021
Plant-Produced Receptor-Binding Domain of SARS-CoV-2 Elicits Potent Neutralizing Responses in Mice and Non-human Primates.
May/13/2021
Longitudinal T-Cell Responses After a Third SARS-CoV-2 Vaccination in Patients With Multiple Sclerosis on Ocrelizumab or Fingolimod
Sep/08/2020
SARS-COV-2 Memory B and T Cells Profile in Mild COVID-19 Convalescents subjects
Apr/23/2021
Systemic IL-15, IFN-gamma, and IP-10/CXCL10 signature associated with effective immune response to SARS-CoV-2 in BNT162b2 mRNA vaccine recipients.
Jul/23/2021
The Cholinergic Drug Pyridostigmine Alleviates Inflammation During LPS-Induced Acute Respiratory Distress Syndrome
May/04/2021
Duration of SARS-CoV-2 Immune Responses Up to Six Months Following Homologous or Heterologous Primary Immunization with ChAdOx1 nCoV-19 and BNT162b2 mRNA Vaccines
Dec/15/2020
Development of humoral and cellular immunological memory against SARS-CoV-2 despite B cell depleting treatment in multiple sclerosis.
Sep/02/2021
Neutralizing antibody-dependent and -independent immune responses against SARS-CoV-2 in cynomolgus macaques.
Dec/29/2020
Selinexor, a novel selective inhibitor of nuclear export, reduces SARS-CoV-2 infection and protects the respiratory system in vivo
Jun/17/2020
A Murine CD8+ T Cell Epitope Identified in the Receptor-Binding Domain of the SARS-CoV-2 Spike Protein.
Jun/11/2021
Kinetics of the B- and T-Cell Immune Responses After 6 Months From SARS-CoV-2 mRNA Vaccination in Patients With Rheumatoid Arthritis
Sep/01/2021
Comparison of Wild Type DNA Sequence of Spike Protein from SARS-CoV-2 with Optimized Sequence on The Induction of Protective Responses Against SARS-Cov-2 Challenge in Mouse Model
Jan/21/2022
Nrf2 Activator PB125 as a Potential Therapeutic Agent against COVID-19
Nov/01/2021
Durability of ChAdOx1 nCoV-19 vaccination in people living with HIV
Nov/12/2021
Tofacitinib therapy intercepts macrophage metabolic reprogramming instigated by SARS-CoV-2 Spike protein
Jun/24/2021
Longitudinal dynamics of SARS-CoV-2-specific cellular and humoral immunity after natural infection or BNT162b2 vaccination
Feb/01/2022
Kabasura Kudineer (KSK), a poly-herbal Siddha medicine, reduced SARS-CoV-2 viral load in asymptomatic COVID-19 individuals as compared to vitamin C and zinc supplementation: findings from a prospective, exploratory, open-labeled, comparative, randomized c
Sep/15/2021
Persistent Spike-specific T cell immunity despite antibody reduction after 3 months from SARS-CoV-2 BNT162b2-mRNA vaccine
May/28/2021
Ruxolitinib, a JAK1/2 Inhibitor, Ameliorates Cytokine Storm in Experimental Models of Hyperinflammation Syndrome.
Apr/22/2021
COVID-19 Subunit Vaccine with a Combination of TLR1/2 and TLR3 Agonists Induces Robust and Protective Immunity
Feb/04/2022
Self-amplifying RNA SARS-CoV-2 lipid nanoparticle vaccine candidate induces high neutralizing antibody titers in mice
May/12/2020
Antiviral effects of human placenta hydrolysate (Laennec ) against SARS-CoV-2 in vitro and in the ferret model
Oct/06/2021
Protective heterologous T cell immunity in COVID-19 induced by the trivalent MMR and Tdap vaccine antigens.
Aug/14/2021
The oral vaccine based on self-replicating RNA lipid nanoparticles can simultaneously neutralize both SARS-CoV-2 variants alpha and delta
Nov/24/2021
Hypothesis: Pentoxifylline is a potential cytokine modulator therapeutic in COVID-19 patients Hypothesis: Pentoxifylline is a potential cytokine modulator therapeutic in COVID-19 patients
Jul/28/2020
Dominant CD8+ T Cell Nucleocapsid Targeting in SARS-CoV-2 Infection and Broad Spike Targeting From Vaccination
Nov/14/2021
Fecal microbiota transplantation for COVID-19; a potential emerging treatment strategy.
Dec/31/2020
Coordinate Induction of Humoral and Spike Specific T-Cell Response in a Cohort of Italian Health Care Workers Receiving BNT162b2 mRNA Vaccine.
Jun/16/2021
Elevated CD21low B Cell Frequency Is a Marker of Poor Immunity to Pfizer-BioNTech BNT162b2 mRNA Vaccine Against SARS-CoV-2 in Patients with Common Variable Immunodeficiency
Mar/15/2022
SARS-CoV-2-reactive interferon-gamma-producing CD8+ T cells in patients hospitalized with coronavirus disease 2019
Jun/15/2020
Janus kinase signaling as risk factor and therapeutic target for severe SARS-CoV-2 infection
May/08/2021
Immunogenicity of Anti-SARS-CoV-2 Vaccines in Common Variable Immunodeficiency
Nov/17/2021
17alpha-Hydroxyprogesterone Caproate Inhibits Cytokine Production via Suppression of NF-kappaB Activation
Feb/07/2022
Recombinant protein subunit SARS-CoV-2 vaccines formulated with CoVaccine HT adjuvant induce broad, Th1 biased, humoral and cellular immune responses in mice
Nov/05/2021
Design of a Novel Multi Epitope-Based Vaccine for Pandemic Coronavirus Disease (COVID-19) by Vaccinomics and Probable Prevention Strategy against Avenging Zoonotics
Jul/02/2020
SARS-CoV-2-specific serological and functional T cell immune responses during acute and early COVID-19 convalescence in solid organ transplant patients
Apr/12/2021
Multi-Epitope Vaccine Design Using an Immunoinformatic Approach for SARS-CoV-2.
Jun/11/2021
Cysteamine with In Vitro Antiviral Activity and Immunomodulatory Effects Has the Potential to Be a Repurposing Drug Candidate for COVID-19 Therapy
Jul/01/2021
Effect of BTN162b2 and CoronaVac boosters on humoral and cellular immunity of individuals previously fully vaccinated with CoronaVac against SARS-CoV-2: A longitudinal study
Feb/15/2021
Immunological analysis of the murine anti-CD3-induced cytokine release syndrome model and therapeutic efficacy of anti-cytokine antibodies
May/19/2021
Novel T cell interferon gamma release assay (IGRA) using spike recombinant protein for COVID19 vaccine response and Nucleocapsid for SARS-Cov2 response
Apr/21/2020
Cytokine release syndrome in a patient with colorectal cancer after vaccination with BNT162b2
Feb/16/2021
Detection of Antibodies Against the SARS-CoV-2 Spike Protein and Analysis of the Peripheral Blood Mononuclear Cell Transcriptomic Profile, 15 Years After Recovery From SARS
Nov/18/2021
T cell response after SARS-CoV-2 vaccination in immunocompromised patients with inflammatory bowel disease
Dec/08/2021
Evaluation of Immune Response and Disease Status in SLE Patients Following SARS-CoV-2 Vaccination
Dec/28/2021
Prevention of Cyclophosphamide-Induced Immunosuppression in Mice With Traditional Chinese Medicine Xuanfei Baidu Decoction
Oct/19/2021
The Effect of Anti-Chemokine Oral Drug XC8 on Cough Triggered by The Agonists of TRPA1 But Not TRPV1 Channels in Guinea Pigs
Apr/18/2020
Evaluation of Humoral and Cellular Responses in SARS-CoV-2 mRNA Vaccinated Immunocompromised Patients
Oct/30/2021
Safety and Immunogenicity of the Third Booster Dose with Inactivated, Viral Vector, and mRNA COVID-19 Vaccines in Fully Immunized Healthy Adults with Inactivated Vaccine
Jan/06/2022
Epitope-based chimeric peptide vaccine design against S, M and E proteins of SARS-CoV-2, the etiologic agent of COVID-19 pandemic: an in silico approach.
Jul/27/2020
Safety and Cross-Variant Immunogenicity of a Three-dose COVID-19 mRNA Vaccine Regimen in Kidney Transplant Recipients
Jan/20/2022
PD-1-Expressing SARS-CoV-2-Specific CD8+ T Cells Are Not Exhausted, but Functional in Patients with COVID-19
Nov/30/2020
Determinants of Immune Response to Anti-SARS-CoV-2 mRNA Vaccines in Kidney Transplant Recipients: A Prospective Cohort Study
Feb/25/2020
SARS-CoV-2-specific CD8+ T-cell responses and TCR signatures in the context of a prominent HLA-A*24:02 allomorph
Sep/30/2021
Kinetics and persistence of cellular and humoral immune responses to SARS-CoV-2 vaccine in healthcare workers with or without prior COVID-19
Jan/18/2022
Successive Site Translocating Inoculation Improved T Cell Responses Elicited by a DNA Vaccine Encoding SARS-CoV-2 S Protein
Nov/01/2020
TRIM28 regulates SARS-CoV-2 cell entry by targeting ACE2
Jun/17/2021
Impact of Prior Influenza and Pneumoccocal Vaccines on Humoral and Cellular Response to SARS-CoV-2 BNT162b2 Vaccination.
Jun/08/2021
Differential immunogenicity of BNT162b2 or ChAdOx1 vaccines after extended-interval homologous dual vaccination in older people.
Aug/20/2021
mRNA Vaccines Enhance Neutralizing Immunity against SARS-CoV-2 Variants in Convalescent and ChAdOx1-Primed Subjects
Aug/27/2020
Humoral and cellular responses after a third dose of SARS-CoV-2 BNT162b2 vaccine in patients with lymphoid malignancies
Feb/14/2022
Adaptive immune responses to SARS-CoV-2 in recovered severe COVID-19 patients.
Aug/08/2021
ImmunosuppressiveTherapies Differently Modulate Humoral- and T-Cell-Specific Responses to COVID-19 mRNA Vaccine in Rheumatoid Arthritis Patients
Sep/14/2021
Highly functional virus-specific cellular immune response in asymptomatic SARS-CoV-2 infection
Apr/28/2020
Effect of a single high dose of Vitamin D3 on cytokines, chemokines and growth factor in patients with moderate to severe COVID-19
Aug/30/2021
Phase 1/2 clinical trial of COVID-19 vaccine in Japanese participants: A report of interim findings
Sep/10/2020
Cellular and Humoral Immune Responses and Breakthrough Infections After Two Doses of BNT162b Vaccine in Healthcare Workers (HW) 180 Days After the Second Vaccine Dose
Apr/17/2020
Comparative immunogenicity analysis of intradermal versus intramuscular administration of SARS-CoV-2 RBD epitope peptide-based immunogen In vivo
Dec/16/2020
Safety and Immunogenicity of a Booster Vaccination by CoronaVac or BNT162b2 in Previously Two-Dose Inactivated Virus Vaccinated Individuals with Negative Neutralizing Antibody
Jan/19/2022
Immunogenicity of COVID-19 mRNA Vaccines in Pregnant and Lactating Women.
May/13/2021
The impact of viral mutations on recognition by SARS-CoV-2 specific T-cells
Oct/28/2021
One or two dose regimen of the SARS-CoV-2 synthetic DNA vaccine INO-4800 protects against respiratory tract disease burden in nonhuman primate challenge model.
Jun/23/2021
SARS-CoV-2-specific immune response in COVID-19 convalescent individuals.
Jul/07/2021
Efficacy and safety of ReDuNing injection as a treatment for COVID-19 and its inhibitory effect against SARS-CoV-2
Jun/24/2021
The effect of immunization with inactivated SARS-CoV-2 vaccine (CoronaVac) and/or SARS-CoV-2 infection on antibody levels, plasmablasts, long-lived-plasma-cells, and IFN-gamma release by natural killer cells
Mar/18/2022
Designing and characterization of a SARS-CoV-2 immunogen with receptor binding motif grafted on a protein scaffold: An epitope-focused vaccine approach
Apr/22/2022
SARS-CoV-2-reactive T-cell receptors isolated from convalescent COVID-19 patients confer potent T-cell effector function
Sep/29/2021
Inactivated SARS-CoV-2 vaccines elicit immunogenicity and T-cell responses in people living with HIV.
Nov/18/2021
Interferon gamma immunotherapy in five critically ill COVID-19 patients with impaired cellular immunity: a case series
Sep/21/2021
The Quality of Anti-SARS-CoV-2 T Cell Responses Predicts the Neutralizing Antibody Titer in Convalescent Plasma Donors
Mar/16/2022
Liushen Capsules, a promising clinical candidate for COVID-19, alleviates SARS-CoV-2-induced pulmonary in vivo and inhibits the proliferation of the variant virus strains in vitro
Apr/01/2022
Broadly directed SARS-CoV-2-specific CD4+ T cell response includes frequently detected peptide specificities within the membrane and nucleoprotein in patients with acute and resolved COVID-19
Sep/16/2021
A snapshot of the immunogenicity, efficacy and safety of a full course of BNT162b2 anti-SARS-CoV-2 vaccine in cancer patients treated with PD-1/PD-L1 inhibitors: a longitudinal cohort study.
Sep/01/2021
SARS-CoV-2 Is Restricted by Zinc Finger Antiviral Protein despite Preadaptation to the Low-CpG Environment in Humans.
Oct/16/2020
Identifying SARS-CoV-2 'memory' NK cells from COVID-19 convalescent donors for adoptive cell therapy
Dec/02/2021
Immunoinformatics prediction of overlapping CD8+ T-cell, IFN-gamma and IL-4 inducer CD4+ T-cell and linear B-cell epitopes based vaccines against COVID-19 (SARS-CoV-2)
Jan/05/2022
Targeting intra-viral conserved nucleocapsid (N) proteins as novel vaccines against SARS-CoVs
Sep/15/2021
T Cell Immunity Evaluation and Immunodominant Epitope T Cell Receptor Identification of Severe Acute Respiratory Syndrome Coronavirus 2 Spike Glycoprotein in COVID-19 Convalescent Patients
May/25/2021
SARS-CoV-2 RBD219-N1C1: A yeast-expressed SARS-CoV-2 recombinant receptor-binding domain candidate vaccine stimulates virus neutralizing antibodies and T-cell immunity in mice
Apr/13/2021
Detection of SARS-CoV-2-independent immunoregulatory activity of COVID-19 convalescent plasma
Oct/08/2021
A triple-blind, placebo-controlled, randomized clinical trial to evaluate the effect of curcumin-containing nanomicelles on cellular immune responses subtypes and clinical outcome in COVID-19 patients
Sep/19/2021
Immune response to SARS-CoV-2 vaccination in relation to peripheral immune cell profiles among patients with multiple sclerosis receiving ocrelizumab
Feb/22/2022
Safety and immunogenicity of Nanocovax, a SARS-CoV-2 recombinant spike protein vaccine: Interim results of a double-blind, randomised controlled phase 1 and 2 trial.
May/16/2022
Impact of an Immune Modulator Mycobacterium-w on Adaptive Natural Killer Cells and Protection Against COVID-19.
May/04/2022
Durability of neutralizing antibodies and T-cell response post SARS-CoV-2 infection.
Oct/05/2020
Differences in Humoral and Cellular Vaccine Responses to SARS-CoV-2 in Kidney and Liver Transplant Recipients
Apr/14/2022
Immunogenic potential of DNA vaccine candidate, ZyCoV-D against SARS-CoV-2 in animal models.
Jun/01/2021
Humoral and cellular responses to spike of delta SARS-CoV-2 variant in vaccinated patients with Immune Mediated Inflammatory Diseases
Apr/22/2022
Safety and immunogenicity of a third-dose homologous BBIBP-CorV boosting vaccination: interim results from a prospective open-label study
Oct/17/2020
Impaired SARS-CoV-2-specific T cell reactivity in patients with cirrhosis following mRNA COVID-19 vaccination
Oct/27/2021
Identification of Highly Conserved SARS-CoV-2 Antigenic Epitopes with Wide Coverage Using Reverse Vaccinology Approach
Nov/11/2021
Continuous Renal Replacement Therapy With oXiris Filter May Not be an Effective Resolution to Alleviate Cytokine Release Syndrome in Non-AKI Patients With Severe and Critical COVID-19
Feb/04/2022
BET inhibition blocks inflammation-induced cardiac dysfunction and SARS-CoV-2 infection.
Mar/16/2021
Exploring the out of sight antigens of SARS-CoV-2 to design a candidate multi-epitope vaccine by utilizing immunoinformatics approaches.
Oct/09/2020
Waning immune responses against SARS-CoV-2 variants of concern among vaccinees in Hong Kong
Mar/03/2022
Targeting the SARS-CoV2 nucleocapsid protein for potential therapeutics using immuno-informatics and structure-based drug discovery techniques.
Oct/20/2020
Synthesis and pharmacological evaluation of choroquine derivatives bearing long aminated side chains as antivirus and anti-inflammatory agents
May/11/2020

Clinical trials

ID Title Status Phase Start date Completion date
NCT04389645 Interferon Gamma Induced Protein 10 (IP-10) in a Clinical Decision Support Protocol in COVID-19 Patients Completed Apr/07/2020 May/12/2020
  • Alternative id - MM-5000-BV
  • Interventions - Diagnostic Test: IP-10 in CDS protocol
  • Study type - Observational
  • Study results - No Results Available
  • Locations - Rabin Medical Center, Petach Tikva, Israel
  • Study designs -
  • Enrollment - 52
  • Age - 18 Years and older   (Adult, Older Adult)
  • Outcome measures - IP-10 levels
NCT05054114 Study of the Use of Nasal IFN-γ in Patients for the Prevention of Acute Respiratory Viral Infections, Icluding COVID-19 Completed Not Applicable Dec/21/2020 Sep/02/2021
  • Alternative id - RAIN-2020
  • Interventions - Drug: Interferon gamma human recombinant (IFN-G)
  • Study type - Interventional
  • Study results - No Results Available
  • Locations - City Clinical Hospital named after M.E. Zhadkevich Moscow City Health Department, Moscow, Russian Federation
  • Study designs - Allocation: Randomized|Intervention Model: Parallel Assignment|Masking: None (Open Label)|Primary Purpose: Prevention
  • Enrollment - 630
  • Age - 18 Years and older   (Adult, Older Adult)
  • Outcome measures - The proportion of patients with acute respiratory viral infections, including COVID-19, at the end of the prophylactic period|The proportion of patients with confirmed COVID-19 at the end of the prophylactic period|The proportion of patients with acute respiratory viral infections, including COVID-19, at the end of the follow-up period|Proportion of patients with confirmed COVID-19 at the end of the follow-up period|The incidence of a complicated course of infection|The proportion of participants with each score of the WHO Clinical Improvement Scale|The duration of symptoms in participants with acute respiratory viral infections, including COVID-19