Imipenem
A beta-lactam (carbapenem) antibiotic.
General information
Imipenem is a beta-lactam antibiotic of the carbapenem subgroup. It is used intravenously (ChEBI).
Imipenem on DrugBank
Imipenem on PubChem
Imipenem on Wikipedia
Marketed as
In a fixed dose with Cilastatin sodium: IMIPENEM AND CILASTATIN; PRIMAXIN
C[C@H]([C@@H]1[C@H]2CC(=C(N2C1=O)C(=O)O)SCCN=CN)O
Supporting references
| Link | Tested on | Impact factor | Notes | Publication date |
|---|---|---|---|---|
|
Drug repurposing of anti-infective clinical drugs: Discovery of two potential anti-cytokine storm agents
Small molecule Animal model |
Male C57BL/6 J mice; murine peritoneal macrophages; human peripheral blood mononuclear cells | 4.55 | Alleviate acute lung injury in mice. Inhibit LPS-stimulated TNF-α and IL-10 in models based on murine peritoneal macrophages or human peipheral blood mononuclear cells. |
Aug/23/2020 |
|
In Silico Structure-Based Repositioning of Approved Drugs for Spike Glycoprotein S2 Domain Fusion Peptide of SARS-CoV-2: Rationale from Molecular Dynamics and Binding Free Energy Calculations
Spike protein Small molecule In silico |
in silico | 6.28 | Predicted to bind the |
Sep/22/2020 |
