Other substances

IMAT-MSCs

Engineered stem cells.

Phase of research

Potential treatment - pre-clinical evidence

How it helps

Other treatment

Drug status

Experimental

1
 Supporting references
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 Contradictory references
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 AI-suggested references
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 Clinical trials

General information

IMAT-MSCs or intercellular mitochondrial transfer-assisted therapeutic mesenchymal stromal (stem) cells are genetically engineered human bone marrow MSCs with a simultaneous knockdown of BAK and overexpression of MCL1. When co-cultured with SARS-CoV-2-infected or NSP4/ORF9b-transduced airway epithelial cells (A549), intercellular mitochondrial transfer via tunnelling nanotubes was observed between IMAT-MSCs and A549 cells. This resulted in alleviation of pro-inflammatory and pro-apoptic release of mitochondrial DNA (Faizan et al., 2022).

 

Supporting references

Link Tested on Impact factor Notes Publication date
NSP4 and ORF9b of SARS-CoV-2 Induce Pro-Inflammatory Mitochondrial DNA Release in Inner Membrane-Derived Vesicles
BM-MSCs Stem cells Cell-based therapy Novel compound In vitro Mechanism Mixed substance 		A549 cells; ACE2/TMPRSS2-expressing A549 cells; NHBE cells 6.60

When co-cultured with SARS-CoV-2-infected or NSP4/ORF9b-transduced airway epithelial cells (A549), intercellular mitochondrial transfer via tunnelling nanotubes was observed between IMAT-MSCs and A549 cells. This resulted in alleviation of pro-inflammatory and pro-apoptic release of mitochondrial DNA. 

 Sep/23/2022
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