Hypothiocyanite

A sulfur oxoacid human metabolite.

Phase of research

Potential treatment - pre-clinical evidence

How it helps

Antiviral

Drug status

Natural product

Supporting references

Contradictory references

AI-suggested references

Clinical trials

Hypothiocyanite is a human metabolite with oxidising and antimicrobial properties (ChEBI).

Hypothiocyanite on PubChem
Hypothiocyanite on Wikipedia

Link	Tested on	Impact factor	Notes	Publication date
Hypothiocyanite and Hypothiocyanite/Lactoferrin Mixture Exhibit Virucidal Activity In Vitro against SARS-CoV-2 Small molecule In vitro	Vero E6 cells; Vero cells; (rVSV) SARS-CoV-2 Spike pseudotyped virus; SARS-CoV-2 live virus (Genbank: MW000351)	3.02	Inhibited SARS-CoV-2 pseudovirus and live virus infection in a dose-dependent and time-dependent (length of pre-incubation) manner with IC50s of ca. 4.64 μM (at MOI of 0.065) and ca. 11 μM, respectively. Cytotoxicity was not observed in Vero cells. The virucidal effect of the compound was enhanced by lactoferrin.	Feb/19/2021