Other substances

Hydroxyitraconazole

An antifungal metabolite.

Phase of research

Potential treatment - pre-clinical evidence

How it helps

Antiviral

Drug status

Experimental

1
 Supporting references
0
 Contradictory references
0
 AI-suggested references
0
 Clinical trials

General information

Hydroxyitraconazole is a metabolite of itaconazole (an antifungal) (Van Damme et al., 2021).

Hydroxyitraconazole on PubChem

Synonyms

17‐OH itraconazole

 

Structure image - Hydroxyitraconazole

CC(C(C)O)N1C(=O)N(C=N1)C2=CC=C(C=C2)N3CCN(CC3)C4=CC=C(C=C4)OCC5COC(O5)(CN6C=NC=N6)C7=C(C=C(C=C7)Cl)Cl

Supporting references

Link Tested on Impact factor Notes Publication date
In vitro activity of itraconazole against SARS‐CoV‐2
Small molecule In vitro 		Caco‐2 cells; VeroE6‐eGFP cells; SARS-CoV-2 strain hCoV-19/Germany/FrankfurtFFM1/2020; SARS-CoV-2 strain BetaCov/Belgium/GHB-03021/2020 2.02

Inhibited SARS-CoV-2 infection in Caco-2 cells in a dose-dependent manner with an EC50 of 1.2 μM and 3.6 μM in two different assays. At 3.1 μM the compound reduced SARS-CoV-2 RNA loads in Caco-2 cells by ca. 2 orders of magnitude.

 Mar/05/2021
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