hu33
An anti-RBD (SARS-CoV-2 Spike) humanized monoclonal antibody.
General information
hu33 is a humanized version of a murine monoclonal antibody (R33) neutralizing SARS-CoV-2. It targets RBD (Duan et al., 2022).
Supporting references
| Link | Tested on | Impact factor | Notes | Publication date |
|---|---|---|---|---|
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A non-ACE2-blocking neutralizing antibody against Omicron-included SARS-CoV-2 variants
Spike protein ACE2 Spike variant Cryo-EM Protein factor Animal model In vitro Mechanism Antibody |
Huh-7 cells; hACE2 mice; (VSV) SARS-CoV-2 Spike-pseudotyped virus (various strains) | 18.19 | Although the antibody was not observed to interfere with RBD (SARS-CoV-2 Spike) binding to ACE2, it did retain some of its capacity to neutralize the virus. It protected hACE2 mice in a viral challenge when used as a prophylaxis or as a treatment. |
Jan/25/2022 |
