hrsACE2

Human recombinant soluble ACE2.

Phase of research

Potential treatment - pre-clinical evidence

How it helps

Antiviral

Drug status

Experimental

2
Supporting references
0
Contradictory references
1
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0
Clinical trials

General information

hrsACE2 is a formulation of human recombinant soluble ACE2 from CHO cells (Monteil et al., 2020).


Synonyms

Human recombinant soluble ACE2

 


Supporting references

Link Tested on Impact factor Notes Publication date
Human soluble ACE2 improves the effect of remdesivir in SARS‐CoV‐2 infection
RdRpol Protein factor Small molecule In vitro
Vero E6 cells; kidney organoids 10.28

Reduces viral load in cell culture and kidney organoids, especially (at low doses) in combination with <a href=

Nov/12/2020
The Omicron variant is highly resistant against antibody-mediated neutralization: Implications for control of the COVID-19 pandemic
Spike protein Spike variant Protein factor Viral vector In vitro Antibody
293T cells; A549-ACE2 cells; BHK-21 cells; Vero cells; Huh-7 cells; Calu-3 cells; Caco-2 cells; (VSV) SARS-CoV-2 Spike pseudoviruses (B.1, Alpha, Beta, Gamma, Delta, or Omicron) 41.58

Soluble ACE2 inhibited SARS-CoV-2 (B.1, Delta, and Omicron) Spike pseudoviral cell entry in vitro. 

Dec/23/2021

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