Hernandezine
A bis-benzylisoquinoline alkaloid.
General information
Hernandezine is a bis-benzylisoquinoline alkaloid. It has been reported to act as a calcium channel blocker and shown to possess anti-SARS-CoV-2 activity in vitro (He et al., 2021).
Hernandezine on PubChem
Hernandezine on Wikipedia
Synonyms
SC161
CN1CCC2=CC(=C3C=C2[C@@H]1CC4=CC=C(C=C4)OC5=C(C=CC(=C5)C[C@H]6C7=C(CCN6C)C(=C(C(=C7O3)OC)OC)OC)OC)OC
Supporting references
| Link | Tested on | Impact factor | Notes | Publication date |
|---|---|---|---|---|
|
Identification of bis-benzylisoquinoline alkaloids as SARS-CoV-2 entry inhibitors from a library of natural products
Small molecule In vitro Mechanism |
in vitro binding assay; 293T-ACE2 cells; Calu-3 cells; A549 cells; Vero E6 cells; (HIV-1) SARS-CoV-2 Spike (D614/G614/B.1.1.7/B.1.351); SARS-CoV-2 live virus | 13.49 | Hernandezine inhibited lentiviral SARS-CoV-2 Spike-pseudotyped virus infection in 293T-ACE2 (EC50 of 0.237 μM or lower, SI >210), Calu-3 and A549 cells. It displayed efficacy also against pseudoviruses with Spike protein of G614, B.1.1.7, B.1.351, SARS, and MERS viruses/strains. The experimental findings suggest that the compound blocks coronavirus entry into host cells by inhibition of calcium ion channels. The compound was also shown to protect Vero E6 cells from SARS-CoV-2 live virus-induced cytopathogenic effect. |
Mar/23/2021 |
