Other substances

Hematopoietic stem cells

Pluripotent cells.

Phase of research

Potential treatment - clinical evidence

How it helps

Other treatment

Drug status

Used to treat other disease

Supporting references

Contradictory references

AI-suggested references

Clinical trials

General information

Hematopoietic stem cells are pluripotent progenitor cells with self-renewal capability. They can differentiate into any haematopoietic system cell (Ng and Alexander, 2017). Transplantation of HSCs is used for the treatment of several haematological, malignant and immune disorders (Duarte et al., 2019).

Hematopoietic stem cells on Wikipedia

Synonyms

Haematopoietic stem cells; HSCs

Supporting references

Link	Tested on	Impact factor	Notes	Publication date
Mild clinical course of SARS-coronavirus-2 infection early posttransplant in patients with adoptively transferred antibody response Stem cells Cell-based therapy Case report Mixed substance	T and B lymphopenia patients	5.48	2 patients who received HSC transplantation due to their medical conditions (not related to COVID-19) were infected with SARS-CoV-2. Despite their immune deficiencies, the infection was mild. One of the patients died 52 days post transplantation with no signs of viral infection. Acute grade 4 graft versus host disease developed in this patient, however. Sample size: 2.	Oct/06/2021

AI-suggested references

Link	Publication date
Human-Immune-System (HIS) humanized mouse model (DRAGA: HLA-A2.HLA-DR4.Rag1KO.IL-2RgammacKO.NOD) for COVID-19.	Mar/29/2022
Kinsenoside attenuates liver fibro-inflammation by suppressing dendritic cells via the PI3K-AKT-FoxO1 pathway	Aug/30/2021
In Vivo Hematopoietic Stem Cell Gene Therapy for SARS-CoV2 Infection Using a Decoy Receptor	Jan/22/2022
Gap Junction-Mediated Cell-Cell Interaction Between Transplanted Mesenchymal Stem Cells and Vascular Endothelium in Stroke	Mar/11/2021
Results and Prospects of Using Activator of Hematopoietic Stem Cell Differentiation in Complex Therapy for Patients with COVID-19	Feb/11/2021
Thymalin: Activation of Differentiation of Human Hematopoietic Stem Cells	Jul/19/2021
Successful Induction of Specific Immunological Tolerance by Combined Kidney and Hematopoietic Stem Cell Transplantation in HLA-Identical Siblings	Oct/15/2021
Development of off-the-shelf hematopoietic stem cell-engineered invariant natural killer T cells for COVID-19 therapeutic intervention	Dec/13/2021
Effectiveness of a third dose of BNT162b2 anti-SARS-CoV-2 mRNA vaccine over a 6-month follow-up period in allogenic hematopoietic stem cells recipients	Apr/29/2022
Curcumin, a traditional spice component, can hold the promise against COVID-19?	Sep/12/2020

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