Hematopoietic stem cells
Potential treatment - clinical evidence
Used to treat other disease
Hematopoietic stem cells are pluripotent progenitor cells with self-renewal capability. They can differentiate into any haematopoietic system cell (Ng and Alexander, 2017). Transplantation of HSCs is used for the treatment of several haematological, malignant and immune disorders (Duarte et al., 2019).
Hematopoietic stem cells on Wikipedia
Haematopoietic stem cells; HSCs
Mild clinical course of SARS-coronavirus-2 infection early posttransplant in patients with adoptively transferred antibody response
Stem cells Cell-based therapy Case report Mixed substance
|T and B lymphopenia patients
2 patients who received HSC transplantation due to their medical conditions (not related to COVID-19) were infected with SARS-CoV-2. Despite their immune deficiencies, the infection was mild. One of the patients died 52 days post transplantation with no signs of viral infection. Acute grade 4 graft versus host disease developed in this patient, however. Sample size: 2.