HB27
A SARS-CoV-2-neutralizing antibody.
General information
HB27 is a humanized murine antibody targeting SARS-CoV-2 Spike RBD, identified using phage display (Zhu et al., 2020). HB27 binds to Spike protein trimers of B.1.1.7 and B.1.351 with comparable affinity. For a standard version of Spike protein, the antibody displayed cooperative binding with antibodies H014, P17, and FC05 (Sun et al., 2021; Wang et al., 2020).
Supporting references
| Link | Tested on | Impact factor | Notes | Publication date |
|---|---|---|---|---|
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Structure-based development of human antibody cocktails against SARS-CoV-2
Spike protein Biophysical assay Animal model In vitro Antibody |
in vitro biophysical assay; 293T cells (cell-to-cell fusion assay); Vero cells; Huh7 cells; hACE2-mice; BALB/c mice | 20.51 | The antibody binds to the SARS-CoV-2 spike protein synergistically with FC05. |
Dec/01/2020 |
|
Structure-based development of three- and four-antibody cocktails against SARS-CoV-2 via multiple mechanisms
Spike protein Cryo-EM Biophysical assay In vitro Antibody |
in vitro biophysical assay; cryo-EM | 20.51 | HB27 bound to Spike protein trimers of B.1.1.7 and B.1.351 with comparable affinity. For a standard version of Spike protein, the antibody displayed cooperative binding with antibodies H014, P17, and FC05. |
Mar/29/2021 |
