Other substances

hACE221-55A36K-F40E

A peptidomimetic binding SARS-CoV-2 Spike protein RBD.

Phase of research

Potential treatment - pre-clinical evidence

How it helps

Antiviral

Drug status

Experimental

1
 Supporting references
0
 Contradictory references
0
 AI-suggested references
0
 Clinical trials

General information

hACE221-55A36K-F40E is a stapled peptide which binds SARS-CoV-2 Spike protein RBD and blocks RBD-hACE2 complex formation in vitro (Maas et al., 2021).

 

Structure image - hACE221-55A36K-F40E

Supporting references

Link Tested on Impact factor Notes Publication date
Targeting SARS-CoV-2 spike protein by stapled hACE2 peptides
Spike protein ACE2 Peptide In vitro 		in vitro biophysical assay 6.00

Inhibited SARS-Co-2 Spike protein-hACE2 complex formation with an IC50 of 3.6 μM.

 Mar/02/2021
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