Other substances

hACE21−740-Fc

A protein Spike decoy.

Phase of research

Potential treatment - pre-clinical evidence

How it helps

Antiviral

Drug status

Experimental

1
 Supporting references
0
 Contradictory references
0
 AI-suggested references
0
 Clinical trials

General information

hACE21−740-Fc is an artificial fusion protein serving as a decoy for SARS-CoV-2 Spike protein. The fusion protein bound SARS-CoV-2 Spike in vitro, blocked viral entry into cells with an IC50 of 0.68 nM and was safe for injection in mice. The protein was stably expressed in modified MSCs (Zhang et al., 2021).

 

Supporting references

Link Tested on Impact factor Notes Publication date
Engineering mesenchymal stromal cells with neutralizing and anti-inflammatory capability against SARS-CoV-2 infection
IL-6 ACE2 Stem cells Protein factor In vitro Antibody 		ACE2 Lenti-X 293 cells; TF-1 cells; C57BL/6J mice (safety profile and fusion protein expression) 6.70

The fusion protein bound SARS-CoV-2 Spike in vitro, blocked viral entry into cells with an IC50 of 0.68 nM and was safe for injection in mice. The protein was stably expressed in modified MSCs. 

 Jun/11/2021
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