Other substances

Go6976

A protein kinase C alpha inhibitor.

Phase of research

Potential treatment - pre-clinical evidence

How it helps

Other treatment

Drug status

Experimental

1
 Supporting references
0
 Contradictory references
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 AI-suggested references
0
 Clinical trials

General information

Go6976 inhibits protein kinase C alpha, which makes it unable to phosphorylate lysine-specific demethylase 1 (LSD1). The phosphorylated form of LSD1 was reported to be responsible for NF-κB p65 stabilization controlling the pro-inflammatory cytokine gene expression (Hong et al., 2020).

Go6976 on PubChem

Synonyms

Goe 6976; Go-6976

 

Structure image - Go6976

Supporting references

Link Tested on Impact factor Notes Publication date
GSK-LSD1, an LSD1 inhibitor, quashes SARS-CoV-2-triggered cytokine release syndrome in-vitro
Severe severity Small molecule In vitro 		COVID-19 patient peripheral blood mononuclear cells 13.49

The S112-phosphorylation of LSD1 protein was found to be more abundant in peripheral blood mononuclear cells (PBMCs) of severe COVID-19 patients compared to non-severe ones. The treatment of PBMCs with Go6976 decreased the proportion of phosphorylated S112 residues within the LSD1 pool, decreased the expression of nuclear NF-κB p65, and improved the cell viability of severe COVID-19 PBMCs. NF-κB p65's methylation was found to be maintained and its stability was reduced.

 Nov/17/2020
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