Ginkgolic acid
A phenolic acid.
General information
Ginkgolic acid is a bioactive phenolic acid (Gerstmeier et al., 2019). It was suggested to act as an irreversible covalent inhibitor of SARS-CoV-2 Papain-like and 3C-like proteases (Chen et al. 2021).
Ginkgolic acid on PubChem
Synonyms
Ginkgolic Acid C15:1
CCCCCC/C=C\CCCCCCCC1=C(C(=CC=C1)O)C(=O)O
Supporting references
| Link | Tested on | Impact factor | Notes | Publication date |
|---|---|---|---|---|
|
Ginkgolic acid and anacardic acid are specific covalent inhibitors of SARS-CoV-2 cysteine proteases
3CLpro PapainLpro Small molecule Enzyme assay In vitro In silico |
in silico; in vitro enzyme assay; Vero E6 cells; SARS-CoV-2 isolate USA-WA1/2020 | 5.03 | Dose-dependently inhibited SARS-CoV-2 Papain-like protease and 3C-like protease with IC50s of ca. 16.3 μM and 1.79 μM, respectively, in vitro. The compound also blocked SARS-CoV-2 replication with an EC50 of ca. 8.3 μM in Vero E6 cells (at sub-cytotoxic concentrations (CC50 of 27.88 μM)). Based on computational modelling and enzyme assay dynamics, gingkolic acid was suggested to act as an irreversible covalent inhibitor of the cysteine proteases. |
Feb/28/2021 |
