GC373
A peptide aldehyde viral 3C-like protease inhibitor.
General information
GC373 is a peptide aldehyde metabolite of GC376. It inhibits coronaviral 3C-like protease and is used for treatment of feline infections (DrugBank).
GC373 on PubChem
Synonyms
Benzyl N-[(2S)-1-[[(2S)-1-hydroxy-3-[(3S)-2-oxopyrrolidin-3-yl]propan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]carbamate
CC(C)C[C@@H](C(=O)N[C@@H](C[C@@H]1CCNC1=O)CO)NC(=O)OCC2=CC=CC=C2
Supporting references
| Link | Tested on | Impact factor | Notes | Publication date |
|---|---|---|---|---|
|
Feline coronavirus drug inhibits the main protease of SARS-CoV-2 and blocks virus replication
3CLpro Small molecule Enzyme assay In vitro |
VERO E6 cell cultures | 12.12 | Effectively inhibit the SARS-CoV-2 3C-like protease in vitro and inhibit SARS-CoV-2 in cell culture. |
Aug/27/2020 |
