Ganciclovir
A nucleotide analogue.
General information
Ganciclovir is a synthetic guanine analogue. Its active metabolite likely inhibits viral DNA replication (NCIt). It is used for treatment of cytomegalovirus infections in immunocompromised patients (ChEBI).
Ganciclovir on DrugBank
Ganciclovir on PubChem
Ganciclovir on Wikipedia
Synonyms
Ganciclovir triphosphate
Marketed as
CYTOVENE; GANCICLOVIR
C1=NC2=C(N1COC(CO)CO)N=C(NC2=O)N
Supporting references
| Link | Tested on | Impact factor | Notes | Publication date |
|---|---|---|---|---|
|
Risk Factors Associated With Acute Respiratory Distress Syndrome and Death in Patients With Coronavirus Disease 2019 Pneumonia in Wuhan, China.
|
Patients | 40.3 % of patients received this therapy |
Mar/13/2020 | |
|
Predicting commercially available antiviral drugs that may act on the novel coronavirus (2019-nCoV), Wuhan, China through a drug-target interaction deep learning model
Preprint In silico |
in silico | Feb/02/2020 | ||
|
A Library of Nucleotide Analogues Terminate RNA Synthesis Catalyzed by Polymerases of Coronaviruses Causing SARS and COVID-19
Preprint |
in vitro | immediate termination of the polymerase reaction |
Apr/25/2020 | |
|
MCCS: a novel recognition pattern-based method for fast track discovery of anti-SARS-CoV-2 drugs
3CLpro Small molecule In silico |
in silico | 8.99 | Predicted to inhibit the SARS-CoV-2 3C-like protease. |
Oct/20/2020 |
