Other substances

Gallium maltolate

A ribonucleotide reductase inhibitor.

Phase of research

Potential treatment - pre-clinical evidence

How it helps

Antiviral

Drug status

Experimental

1
 Supporting references
0
 Contradictory references
0
 AI-suggested references
0
 Clinical trials

General information

Gallium maltolate is a bioavailable coordination compound. It contains trivalent gallium cation. Gallium maltolate was observed to have anti-inflammatory, anti-proliferative, antineoplastic, analgesic, antiresorptive and antibacterial properties. It is active via ribonucleotide reductase inhibition, which results in impediment of DNA synthesis and cell death in rapidly proliferating cells or bacteria. Gallium maltolate may also interfere with the activity of other enzymes, which could explain its biological properties (NCIt).

Gallium maltolate on DrugBank
Gallium maltolate on PubChem
Gallium maltolate on Wikipedia


 

Structure image - Gallium maltolate

CC1=C(C(=O)C=CO1)[O-].CC1=C(C(=O)C=CO1)[O-].CC1=C(C(=O)C=CO1)[O-].[Ga+3]

Supporting references

Link Tested on Impact factor Notes Publication date
Gallium maltolate has in vitro antiviral activity against SARS-CoV-2 and is a potential treatment for COVID-19
Small molecule In vitro 		Vero E6 cells; SARS-CoV-2 strain hCoV-19/Wuhan/WIV04/2019 1.89

Inhibited SARS-CoV-2 replication in a dose-dependent manner with EC50 of ca. 14 µM in Vero E6 cells and no cytotoxic effect to concentration of at least 200 µM.

 Dec/22/2020
Export (.csv)