Other substances

Flupirtine

A nonopioid analgesic.

Phase of research

Potential treatment - pre-clinical evidence

How it helps

Antiviral

Drug status

Used to treat other disease

1
 Supporting references
0
 Contradictory references
0
 AI-suggested references
0
 Clinical trials

General information

Flupirtine is a pyridine derivate used as a non-opioid analgesic. It is active, for example, as a potassium channel activator and NMDA receptor antagonist (DrugBank). The compound acted as a TMPRSS2 inhibitor in an enzyme assay and suppressed TMPRSS-dependent SARS-CoV-2 Spike-pseudotyped virus infection in vitro (Chen et al., 2021).

Flupirtine on PubChem
Flupirtine on Wikipedia


Marketed as

AWEGAL; EFFIRMA; EFIRET; KATADOLON; METANOR; TRANCOLONG

 

Structure image - Flupirtine

CCOC(=O)NC1=C(N=C(C=C1)NCC2=CC=C(C=C2)F)N

Supporting references

Link Tested on Impact factor Notes Publication date
Screening strategy of TMPRSS2 inhibitors by FRET-based enzymatic activity for TMPRSS2-based cancer and COVID-19 treatment
TMPRSS2 Small molecule Enzyme assay In vitro Mechanism 		in vitro enzyme assay; Vero E6 cells; Vero E6 cells overexpressing TMPRSS2 5.18

The compound acted as a TMPRSS2 inhibitor in an enzyme assay. It also blocked the infection in standard Vero cells, but the efficacy was significantly higher in TMPRSS2-overexpressing cells.

 Mar/01/2021
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