Other substances

Flupentixol

A thioxanthene dopamine D1 and D2 receptor antagonist.

Phase of research

Potential treatment - pre-clinical evidence

How it helps

Antiviral

Drug status

Used to treat other disease

1
 Supporting references
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 Contradictory references
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 AI-suggested references
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 Clinical trials

General information

Flupentixol is an antipsychotic neuroleptic thioxanthene. It acts as a dopamine D1 and D2 receptor antagonist (DrugBank).

Flupentixol on PubChem
Flupentixol on Wikipedia

Marketed as

DEPIXOL; FLUANXOL; FLUPENTIXOL DECANOATE; JEXIT

 

Structure image - Flupentixol

C1CN(CCN1CC/C=C\2/C3=CC=CC=C3SC4=C2C=C(C=C4)C(F)(F)F)CCO

Supporting references

Link Tested on Impact factor Notes Publication date
Identification of SARS-CoV-2 entry inhibitors among already approved drugs
Small molecule In vitro Screening 		Huh-7 cells (pseudovirus-based assay); Vero E6 cells (antiviral activity); SARS-CoV-2 (WIV04) 5.06

Inhibits SARS-CoV-2 spike protein pseudovirus cell entry and significally inhibits viral replication in vitro.

 Oct/28/2020
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