Other substances

Fludarabine

A purine analogue.

Phase of research

Potential treatment - pre-clinical evidence

How it helps

Antiviral

Drug status

Used to treat other disease

2
 Supporting references
0
 Contradictory references
3
 AI-suggested references
0
 Clinical trials

General information

Fludarabine is a purine analogue used in the treatment of chronic lymphocytic leukaemia and as an immunosuppressant (LiverTox).

Fludarabine on DrugBank
Fludarabine on PubChem
Fludarabine on Wikipedia

Marketed as

FLUDARA; FLUDARABINE PHOSPHATE; OFORTA

 

Structure image - Fludarabine

C1=NC2=C(N=C(N=C2N1[C@H]3[C@H]([C@@H]([C@H](O3)CO)O)O)F)N

Supporting references

Link Tested on Impact factor Notes Publication date
Evaluation of the potency of FDA-approved drugs on wild type and mutant SARS-CoV-2 helicase (Nsp13)
nsp13 Small molecule In silico 		in silico 5.16

Predicted to inhibit the SARS-CoV-2 nsp13 helicase (both wild type and with C17747T and A17858G mutations).

 Sep/24/2020
Blockers of the SARS-CoV-2 3a Channel Identified by Targeted Drug Repurposing
Small molecule In vitro 		in vitro bacteria-based assay 3.82

Displayed inhibitory activity against the potential ion channel ORF3a of SARS-CoV-2 in a bacterial model assay.

 Mar/23/2021

AI-suggested references

Link Publication date
A new high-content screening assay of the entire hepatitis B virus life cycle identifies novel antivirals.
Apr/30/2021
5-Iodotubercidin inhibits SARS-CoV-2 RNA synthesis
Jan/29/2022
Protracted or recurrent COVID-19 associated cytokine storm in a patient with chronic lymphocytic leukemia receiving rituximab-based chemotherapy
Mar/23/2022
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